Role of TRPV receptors in respiratory diseases

Yanlin Jia, Lu Yuan Lee

Research output: Contribution to journalReview articlepeer-review

113 Scopus citations


Transient receptor potential vanilloid type channels (TRPVs) are expressed in several cell types in human and animal lungs. Increasing evidence has demonstrated important roles of these cation channels, particularly TRPV1 and TRPV4, in the regulation of airway function. These TRPVs can be activated by a number of endogenous substances (hydrogen ion, certain lipoxygenase products, etc.) and changes in physiological conditions (e.g., temperature, osmolarity, etc.). Activation of these channels can evoke Ca2+ influx and excitation of the neuron. TRPV1 channels are generally expressed in non-myelinated afferents innervating the airways and lungs, which also contain sensory neuropeptides such as tachykinins. Upon stimulation, these sensory nerves elicit centrally-mediated reflex responses as well as local release of tachykinins, and result in cough, airway irritation, reflex bronchoconstriction and neurogenic inflammation in the airways. Recent studies clearly demonstrated that the excitability of TRPV1 channels is up-regulated by certain autacoids (e.g., prostaglandin E2, bradykinin) released during airway inflammatory reaction. Under these conditions, the TRPV1 can be activated by a slight increase in airway temperature or tissue acidity. Indirect evidence also suggests that TRPV channels may play a part in the pathogenesis of certain respiratory diseases such as asthma and chronic cough. Therefore, the potential use of TRPV antagonists as a novel therapy for these diseases certainly merits further investigation.

Original languageEnglish
Pages (from-to)915-927
Number of pages13
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Issue number8
StatePublished - Aug 2007

Bibliographical note

Funding Information:
The work was supported in part by grants from the National Institutes of Health (HL-58686 and HL-67379) to LYL. The authors thank Michelle Wiggers for her assistance in the preparation of this review.


  • Chronic cough
  • Inflammation
  • Neuropeptide
  • Respiratory disease
  • TRPV

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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