Role of TRPV1 in inflammation-induced airway hypersensitivity

Lu Yuan Lee, Qihai Gu

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations

Abstract

Airway hypersensitivity is a common pathophysiological feature in various airway inflammatory diseases. Increasing evidence suggests that activation of the transient receptor potential vanilloid type 1 receptor (TRPV1) plays an important part in the manifestation of various symptoms of airway hypersensitivity. This mini-review focuses on recent studies that have revealed several potential contributing factors to the increase in TRPV1 sensitivity in pulmonary sensory neurons during airway inflammatory reaction. In addition, chronic allergic airway inflammation induces a pronounced overexpression of TRPV1 in neurofilament-positive pulmonary sensory neurons in nodose ganglia. A better understanding of the mechanisms underlying the increase in sensitivity and/or expression of TRPV1 during acute and chronic airway inflammation should generate the necessary information for developing effective therapeutic interventions to alleviate airway hypersensitivity.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume9
Issue number3
DOIs
StatePublished - Jun 2009

Bibliographical note

Funding Information:
The work was supported in part by USPHS grants from the National Institutes of Health (HL58686 to L-YL; AI76714 to QG).

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Role of TRPV1 in inflammation-induced airway hypersensitivity'. Together they form a unique fingerprint.

Cite this