Roles for lipid phosphate phosphatases in regulation of cellular signaling

Vicki A. Sciorra, Andrew J. Morris

Research output: Contribution to journalReview articlepeer-review

148 Scopus citations

Abstract

Lipid phosphate phosphatases (LPPs) are a family of integral membrane glycoproteins that catalyze the dephosphorylation of a number of bioactive lipid mediators including lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and phosphatidic acid (PA). These mediators exert complex effects on cell function through both actions at cell surface receptors and on intracellular targets. The LPP-catalyzed dephosphorylation of these substrates can both terminate their signaling actions and itself generate further molecules with biological activity. Recent advances have revealed that a family of structurally related genes is responsible for LPP activities in species from yeast to mammals. These genes exhibit distinct but overlapping expression patterns and their products appear to be heterogeneous with respect to their posttranslational modification and subcellular localizations. Here we review the structure and catalytic properties of the LPPs and consider recent developments in understanding their cellular biology and functions.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1582
Issue number1-3
DOIs
StatePublished - May 23 2002

Bibliographical note

Funding Information:
Research in the Author's Laboratories is supported by grants from the National Institutes of Health and American Heart Association.

Keywords

  • Lipid phosphate phosphatase
  • Lysophosphatidic acid
  • Sphingosine phosphate

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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