Roles for sphingolipids in saccharomyces cerevisiae

Robert C. Dickson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

79 Scopus citations

Abstract

Studies using Saccharomyces cerevisiae, the common baker's or brewer's yeast, have progressed over the past twenty years from knowing which sphingolipids are present in cells and a basic outline of how they are made to a complete or nearly complete directory of the genes that catalyze their anabolism and catabolism. In addition, cellular processes that depend upon sphingolipids have been identified including protein trafficking/exocytosis, endocytosis and actin cytoskeleton dynamics, membrane microdomains, calcium signaling, regulation of transcription and translation, cell cycle control, stress resistance, nutrient uptake and aging. These will be summarized here along with new data not previously reviewed. Advances in our knowledge of sphingolipids and their roles in yeast are impressive but molecular mechanisms remain elusive and are a primary challenge for further progress in understanding the specific functions of sphingolipids.

Original languageEnglish
Title of host publicationSphingolipids as Signaling and Regulatory Molecules
EditorsCharles Chalfant, Maurizio Del Poeta
Pages217-231
Number of pages15
DOIs
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume688
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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