TY - CHAP
T1 - Roles for sphingolipids in saccharomyces cerevisiae
AU - Dickson, Robert C.
PY - 2010
Y1 - 2010
N2 - Studies using Saccharomyces cerevisiae, the common baker's or brewer's yeast, have progressed over the past twenty years from knowing which sphingolipids are present in cells and a basic outline of how they are made to a complete or nearly complete directory of the genes that catalyze their anabolism and catabolism. In addition, cellular processes that depend upon sphingolipids have been identified including protein trafficking/exocytosis, endocytosis and actin cytoskeleton dynamics, membrane microdomains, calcium signaling, regulation of transcription and translation, cell cycle control, stress resistance, nutrient uptake and aging. These will be summarized here along with new data not previously reviewed. Advances in our knowledge of sphingolipids and their roles in yeast are impressive but molecular mechanisms remain elusive and are a primary challenge for further progress in understanding the specific functions of sphingolipids.
AB - Studies using Saccharomyces cerevisiae, the common baker's or brewer's yeast, have progressed over the past twenty years from knowing which sphingolipids are present in cells and a basic outline of how they are made to a complete or nearly complete directory of the genes that catalyze their anabolism and catabolism. In addition, cellular processes that depend upon sphingolipids have been identified including protein trafficking/exocytosis, endocytosis and actin cytoskeleton dynamics, membrane microdomains, calcium signaling, regulation of transcription and translation, cell cycle control, stress resistance, nutrient uptake and aging. These will be summarized here along with new data not previously reviewed. Advances in our knowledge of sphingolipids and their roles in yeast are impressive but molecular mechanisms remain elusive and are a primary challenge for further progress in understanding the specific functions of sphingolipids.
UR - http://www.scopus.com/inward/record.url?scp=78049504286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049504286&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-6741-1_15
DO - 10.1007/978-1-4419-6741-1_15
M3 - Chapter
C2 - 20919657
AN - SCOPUS:78049504286
SN - 9781441967404
T3 - Advances in Experimental Medicine and Biology
SP - 217
EP - 231
BT - Sphingolipids as Signaling and Regulatory Molecules
A2 - Chalfant, Charles
A2 - Del Poeta, Maurizio
ER -