TY - JOUR
T1 - Roles of Krüppel-like factor 4 in normal homeostasis, cancer and stem cells
AU - Evans, Paul M.
AU - Liu, Chunming
PY - 2008/7
Y1 - 2008/7
N2 - Krüppel-like factor 4 (KLF4) is a zinc finger-type transcription factor expressed in a variety of tissues, including the epithelium of the intestine and the skin, and it plays an important role in differentiation and cell cycle arrest. Depending on the gene targeted, KLF4 can both activate and repress transcription. Moreover, in certain cellular contexts, KLF4 can function as a tumor suppressor or an oncogene. Finally, KLF4 is important in reprogramming differentiated fibroblasts into inducible pluripotent stem cells, which highly resemble embryonic stem cells. This review summarizes what is known about the diverse functions of KLF4 as well as their molecular mechanisms.
AB - Krüppel-like factor 4 (KLF4) is a zinc finger-type transcription factor expressed in a variety of tissues, including the epithelium of the intestine and the skin, and it plays an important role in differentiation and cell cycle arrest. Depending on the gene targeted, KLF4 can both activate and repress transcription. Moreover, in certain cellular contexts, KLF4 can function as a tumor suppressor or an oncogene. Finally, KLF4 is important in reprogramming differentiated fibroblasts into inducible pluripotent stem cells, which highly resemble embryonic stem cells. This review summarizes what is known about the diverse functions of KLF4 as well as their molecular mechanisms.
KW - Colorectal cancer
KW - Krüppel-like factor 4
KW - Stem cell
UR - http://www.scopus.com/inward/record.url?scp=47549096256&partnerID=8YFLogxK
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U2 - 10.1111/j.1745-7270.2008.00439.x
DO - 10.1111/j.1745-7270.2008.00439.x
M3 - Review article
C2 - 18604447
AN - SCOPUS:47549096256
SN - 1672-9145
VL - 40
SP - 554
EP - 564
JO - Acta Biochimica et Biophysica Sinica
JF - Acta Biochimica et Biophysica Sinica
IS - 7
ER -
