Abstract
Krüppel-like factor 4 (KLF4) is a zinc finger-type transcription factor expressed in a variety of tissues, including the epithelium of the intestine and the skin, and it plays an important role in differentiation and cell cycle arrest. Depending on the gene targeted, KLF4 can both activate and repress transcription. Moreover, in certain cellular contexts, KLF4 can function as a tumor suppressor or an oncogene. Finally, KLF4 is important in reprogramming differentiated fibroblasts into inducible pluripotent stem cells, which highly resemble embryonic stem cells. This review summarizes what is known about the diverse functions of KLF4 as well as their molecular mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 554-564 |
| Number of pages | 11 |
| Journal | Acta Biochimica et Biophysica Sinica |
| Volume | 40 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2008 |
Funding
| Funders | Funder number |
|---|---|
| National Childhood Cancer Registry – National Cancer Institute | T32CA117834 |
| National Childhood Cancer Registry – National Cancer Institute |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Colorectal cancer
- Krüppel-like factor 4
- Stem cell
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
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