Roles of lysophosphatidic acid in cardiovascular physiology and disease

Susan S. Smyth, Hsin Yuan Cheng, Sumitra Miriyala, Manikandan Panchatcharam, Andrew J. Morris

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


The bioactive lipid mediator lysophosphatidic acid (LPA) exerts a range of effects on the cardiovasculature that suggest a role in a variety of critical cardiovascular functions and clinically important cardiovascular diseases. LPA is an activator of platelets from a majority of human donors identifying a possible role as a regulator of acute thrombosis and platelet function in atherogenesis and vascular injury responses. Of particular interest in this context, LPA is an effective phenotypic modulator of vascular smooth muscle cells promoting the de-differentiation, proliferation and migration of these cells that are required for the development of intimal hyperplasia. Exogenous administration of LPA results in acute and systemic changes in blood pressure in different animal species, suggesting a role for LPA in both normal blood pressure regulation and hypertension. Advances in our understanding of the molecular machinery responsible for the synthesis, actions and inactivation of LPA now promise to provide the tools required to define the role of LPA in cardiovascular physiology and disease. In this review we discuss aspects of LPA signaling in the cardiovasculature focusing on recent advances and attempting to highlight presently unresolved issues and promising avenues for further investigation.

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Issue number9
StatePublished - Sep 2008


  • Lysophosphatidic acid Cardiovascular disease

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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