RORα, a potential tumor suppressor and therapeutic target of breast cancer

Jun Du, Ren Xu

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

The function of the nuclear receptor (NR) in breast cancer progression has been investigated for decades. The majority of the nuclear receptors have well characterized natural ligands, but a few of them are orphan receptors for which no ligand has been identified. RORα, one member of the retinoid orphan nuclear receptor (ROR) subfamily of orphan receptors, regulates various cellular and pathological activities. RORα is commonly down-regulated and/or hypoactivated in breast cancer compared to normal mammary tissue. Expression of RORα suppresses malignant phenotypes in breast cancer cells, in vitro and in vivo. Activity of RORα can be categorized into the canonical and non-canonical nuclear receptor pathways, which in turn regulate various breast cancer cellular function, including cell proliferation, apoptosis and invasion. This information suggests that RORα is a potent tumor suppressor and a potential therapeutic target for breast cancer.

Original languageEnglish
Pages (from-to)15755-15766
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume13
Issue number12
DOIs
StatePublished - Dec 2012

Keywords

  • Breast cancer
  • RORa
  • Therapeutic target
  • Tumor suppressor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'RORα, a potential tumor suppressor and therapeutic target of breast cancer'. Together they form a unique fingerprint.

Cite this