Ruthmycin, a new Tetracyclic Polyketide from Streptomyces sp. RM-4-15

Xiachang Wang, Sherif I. Elshahawi, Khaled A. Shaaban, Lei Fang, Larissa V. Ponomareva, Yinan Zhang, Gregory C. Copley, James C. Hower, Chang Guo Zhan, Madan K. Kharel, Jon S. Thorson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalOrganic Letters
Volume16
Issue number2
DOIs
StatePublished - Jan 17 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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