@article{11e0f48c24ff4cbcb8cc02093e204ae7,
title = "Ruthmycin, a new Tetracyclic Polyketide from Streptomyces sp. RM-4-15",
abstract = "The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.",
author = "Xiachang Wang and Elshahawi, \{Sherif I.\} and Shaaban, \{Khaled A.\} and Lei Fang and Ponomareva, \{Larissa V.\} and Yinan Zhang and Copley, \{Gregory C.\} and Hower, \{James C.\} and Zhan, \{Chang Guo\} and Kharel, \{Madan K.\} and Thorson, \{Jon S.\}",
year = "2014",
month = jan,
day = "17",
doi = "10.1021/ol4033418",
language = "English",
volume = "16",
pages = "456--459",
number = "2",
}