Ruthmycin, a new Tetracyclic Polyketide from Streptomyces sp. RM-4-15

Xiachang Wang; Sherif I. Elshahawi; Khaled A. Shaaban; Lei Fang; Larissa V. Ponomareva; Yinan Zhang; Gregory C. Copley; James C. Hower; Chang Guo Zhan; Madan K. Kharel; Jon S. Thorson

doi:10.1021/ol4033418

Ruthmycin, a new Tetracyclic Polyketide from Streptomyces sp. RM-4-15

Xiachang Wang, Sherif I. Elshahawi, Khaled A. Shaaban, Lei Fang, Larissa V. Ponomareva, Yinan Zhang, Gregory C. Copley, James C. Hower, Chang Guo Zhan, Madan K. Kharel, Jon S. Thorson

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24 Scopus citations

Abstract

The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

Original language	English
Pages (from-to)	456-459
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	2
DOIs	https://doi.org/10.1021/ol4033418
State	Published - Jan 17 2014

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol4033418

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title = "Ruthmycin, a new Tetracyclic Polyketide from Streptomyces sp. RM-4-15",

abstract = "The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.",

author = "Xiachang Wang and Elshahawi, {Sherif I.} and Shaaban, {Khaled A.} and Lei Fang and Ponomareva, {Larissa V.} and Yinan Zhang and Copley, {Gregory C.} and Hower, {James C.} and Zhan, {Chang Guo} and Kharel, {Madan K.} and Thorson, {Jon S.}",

year = "2014",

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doi = "10.1021/ol4033418",

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T1 - Ruthmycin, a new Tetracyclic Polyketide from Streptomyces sp. RM-4-15

AU - Wang, Xiachang

AU - Elshahawi, Sherif I.

AU - Shaaban, Khaled A.

AU - Fang, Lei

AU - Ponomareva, Larissa V.

AU - Zhang, Yinan

AU - Copley, Gregory C.

AU - Hower, James C.

AU - Zhan, Chang Guo

AU - Kharel, Madan K.

AU - Thorson, Jon S.

PY - 2014/1/17

Y1 - 2014/1/17

N2 - The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

AB - The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

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JO - Organic Letters

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Ruthmycin, a new Tetracyclic Polyketide from Streptomyces sp. RM-4-15

Abstract

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