S100β is a calcium-binding protein elevated in Down's syndrome and Alzheimer's disease. Previous studies have demonstrated that S100β is trophic for several neuronal populations. We tested the influence of S100β on hippocampal neurons. The initial response included a rapid increase in [Ca2+]i similar to that elicited by S100β in other populations. S100β also substantially decreased cell death and loss of mitochondrial function resulting from glucose deprivation. Therefore, S100β exerts a neuroprotective influence on CNS neurons, suggesting that its elevation in neurological disorders may be a compensatory response.
|Number of pages||4|
|State||Published - Apr 17 1995|
Bibliographical noteFunding Information:
This work was supported in part by funds from the NIH (S.W.B., M.P.M., and L.V.E.), the Alzheimer's Association (M.P.M.), and the French Foundation (S.W.B.). We are grateful to Stefan Strack for helpful discussion.
ASJC Scopus subject areas
- Neuroscience (all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology