S100β protects hippocampal neurons from damage induced by glucose deprivation

Steven W. Barger; Linda J. Van Eldik; Mark P. Mattson

doi:10.1016/0006-8993(95)00160-R

S100β protects hippocampal neurons from damage induced by glucose deprivation

Steven W. Barger, Linda J. Van Eldik, Mark P. Mattson

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

S100β is a calcium-binding protein elevated in Down's syndrome and Alzheimer's disease. Previous studies have demonstrated that S100β is trophic for several neuronal populations. We tested the influence of S100β on hippocampal neurons. The initial response included a rapid increase in [Ca²⁺]_i similar to that elicited by S100β in other populations. S100β also substantially decreased cell death and loss of mitochondrial function resulting from glucose deprivation. Therefore, S100β exerts a neuroprotective influence on CNS neurons, suggesting that its elevation in neurological disorders may be a compensatory response.

Original language	English
Pages (from-to)	167-170
Number of pages	4
Journal	Brain Research
Volume	677
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(95)00160-R
State	Published - Apr 17 1995

Bibliographical note

Funding Information:
This work was supported in part by funds from the NIH (S.W.B., M.P.M., and L.V.E.), the Alzheimer's Association (M.P.M.), and the French Foundation (S.W.B.). We are grateful to Stefan Strack for helpful discussion.

Funding

This work was supported in part by funds from the NIH (S.W.B., M.P.M., and L.V.E.), the Alzheimer's Association (M.P.M.), and the French Foundation (S.W.B.). We are grateful to Stefan Strack for helpful discussion.

Funders	Funder number
French Fyssen Foundation
National Institutes of Health (NIH)
Alzheimer's Association

Keywords

Calcium
Glucose
Hippocampus
Mitochondria
Neurotrophic
S100

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(95)00160-R

Cite this

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title = "S100β protects hippocampal neurons from damage induced by glucose deprivation",

abstract = "S100β is a calcium-binding protein elevated in Down's syndrome and Alzheimer's disease. Previous studies have demonstrated that S100β is trophic for several neuronal populations. We tested the influence of S100β on hippocampal neurons. The initial response included a rapid increase in [Ca2+]i similar to that elicited by S100β in other populations. S100β also substantially decreased cell death and loss of mitochondrial function resulting from glucose deprivation. Therefore, S100β exerts a neuroprotective influence on CNS neurons, suggesting that its elevation in neurological disorders may be a compensatory response.",

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AU - Van Eldik, Linda J.

AU - Mattson, Mark P.

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AB - S100β is a calcium-binding protein elevated in Down's syndrome and Alzheimer's disease. Previous studies have demonstrated that S100β is trophic for several neuronal populations. We tested the influence of S100β on hippocampal neurons. The initial response included a rapid increase in [Ca2+]i similar to that elicited by S100β in other populations. S100β also substantially decreased cell death and loss of mitochondrial function resulting from glucose deprivation. Therefore, S100β exerts a neuroprotective influence on CNS neurons, suggesting that its elevation in neurological disorders may be a compensatory response.

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KW - Neurotrophic

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S100β protects hippocampal neurons from damage induced by glucose deprivation

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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