S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis

Brenda S. McAdory, Linda J. Van Eldik, Jeanette J. Norden

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Using light and electron microscopic immunocytochemistry, we examined the expression of the Ca2+-binding protein S100B in the dentate gyrus of adult rats during lesion-induced sprouting and reactive synaptogenesis. Nine days following unilateral lesioning of the entorhinal cortex, S100B was upregulated in cells primarily in the outer part of the molecular layer of the ipsilateral dentate gyrus. When examined with electron microscopy, numerous astrocytes and synapses containing S100B were identified. These data show that during lesion-induced sprouting and reactive synaptogenesis, S100B is upregulated in astrocytes and can be found in pre- and post-synaptic compartments where it might influence neuronal protein phosphorylation.

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalBrain Research
Volume813
Issue number1
DOIs
StatePublished - Nov 30 1998

Bibliographical note

Funding Information:
We would like to thank Jesse Britton for help with the electron microscopy and Nancy Cardwell for photography. This work was supported by National Institute of Health Grants NS25150 (to J.J.N.) and AG15501 (to L.V.E.).

Keywords

  • Astrogliosis
  • Axon growth
  • Glial- released protein
  • Hippocampus
  • Neurotropic factor
  • S100B
  • Sprouting

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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