S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis

Brenda S. McAdory; Linda J. Van Eldik; Jeanette J. Norden

doi:10.1016/S0006-8993(98)01014-2

S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis

Brenda S. McAdory, Linda J. Van Eldik, Jeanette J. Norden

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Using light and electron microscopic immunocytochemistry, we examined the expression of the Ca²⁺-binding protein S100B in the dentate gyrus of adult rats during lesion-induced sprouting and reactive synaptogenesis. Nine days following unilateral lesioning of the entorhinal cortex, S100B was upregulated in cells primarily in the outer part of the molecular layer of the ipsilateral dentate gyrus. When examined with electron microscopy, numerous astrocytes and synapses containing S100B were identified. These data show that during lesion-induced sprouting and reactive synaptogenesis, S100B is upregulated in astrocytes and can be found in pre- and post-synaptic compartments where it might influence neuronal protein phosphorylation.

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	Brain Research
Volume	813
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)01014-2
State	Published - Nov 30 1998

Bibliographical note

Funding Information:
We would like to thank Jesse Britton for help with the electron microscopy and Nancy Cardwell for photography. This work was supported by National Institute of Health Grants NS25150 (to J.J.N.) and AG15501 (to L.V.E.).

Keywords

Astrogliosis
Axon growth
Glial- released protein
Hippocampus
Neurotropic factor
S100B
Sprouting

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(98)01014-2

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title = "S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis",

abstract = "Using light and electron microscopic immunocytochemistry, we examined the expression of the Ca2+-binding protein S100B in the dentate gyrus of adult rats during lesion-induced sprouting and reactive synaptogenesis. Nine days following unilateral lesioning of the entorhinal cortex, S100B was upregulated in cells primarily in the outer part of the molecular layer of the ipsilateral dentate gyrus. When examined with electron microscopy, numerous astrocytes and synapses containing S100B were identified. These data show that during lesion-induced sprouting and reactive synaptogenesis, S100B is upregulated in astrocytes and can be found in pre- and post-synaptic compartments where it might influence neuronal protein phosphorylation.",

keywords = "Astrogliosis, Axon growth, Glial- released protein, Hippocampus, Neurotropic factor, S100B, Sprouting",

author = "McAdory, {Brenda S.} and {Van Eldik}, {Linda J.} and Norden, {Jeanette J.}",

note = "Funding Information: We would like to thank Jesse Britton for help with the electron microscopy and Nancy Cardwell for photography. This work was supported by National Institute of Health Grants NS25150 (to J.J.N.) and AG15501 (to L.V.E.). ",

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AU - McAdory, Brenda S.

AU - Van Eldik, Linda J.

AU - Norden, Jeanette J.

N1 - Funding Information: We would like to thank Jesse Britton for help with the electron microscopy and Nancy Cardwell for photography. This work was supported by National Institute of Health Grants NS25150 (to J.J.N.) and AG15501 (to L.V.E.).

PY - 1998/11/30

Y1 - 1998/11/30

N2 - Using light and electron microscopic immunocytochemistry, we examined the expression of the Ca2+-binding protein S100B in the dentate gyrus of adult rats during lesion-induced sprouting and reactive synaptogenesis. Nine days following unilateral lesioning of the entorhinal cortex, S100B was upregulated in cells primarily in the outer part of the molecular layer of the ipsilateral dentate gyrus. When examined with electron microscopy, numerous astrocytes and synapses containing S100B were identified. These data show that during lesion-induced sprouting and reactive synaptogenesis, S100B is upregulated in astrocytes and can be found in pre- and post-synaptic compartments where it might influence neuronal protein phosphorylation.

AB - Using light and electron microscopic immunocytochemistry, we examined the expression of the Ca2+-binding protein S100B in the dentate gyrus of adult rats during lesion-induced sprouting and reactive synaptogenesis. Nine days following unilateral lesioning of the entorhinal cortex, S100B was upregulated in cells primarily in the outer part of the molecular layer of the ipsilateral dentate gyrus. When examined with electron microscopy, numerous astrocytes and synapses containing S100B were identified. These data show that during lesion-induced sprouting and reactive synaptogenesis, S100B is upregulated in astrocytes and can be found in pre- and post-synaptic compartments where it might influence neuronal protein phosphorylation.

KW - Astrogliosis

KW - Axon growth

KW - Glial- released protein

KW - Hippocampus

KW - Neurotropic factor

KW - S100B

KW - Sprouting

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SN - 0006-8993

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JF - Brain Research

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S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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