TY - JOUR
T1 - Safe haven
T2 - The cell biology of nonfusogenic pathogen vacuoles
AU - Sinai, Anthony P.
AU - Joiner, Keith A.
PY - 1997
Y1 - 1997
N2 - Our understanding of both membrane traffic in mammalian cells and the cell biology of infection with intracellular pathogens has increased dramatically in recent years. In this review, we discuss the cell biology of the host-microbe interaction for four intracellular pathogens: Chlamydia spp., Legionella pneumophila, Mycobacterium spp., and the protozoan parasite Toxoplasma gondii. All of these organisms reside in vacuoles inside cells that have restricted fusion with host organelles of the endocytic cascade. Despite this restricted fusion, the vacuoles surrounding each pathogen display novel interactions with other host cell organelles. In addition to the effect of infection on host membrane traffic, we focus on these novel interactions and relate them where possible to nutrient acquisition by the intracellular organisms.
AB - Our understanding of both membrane traffic in mammalian cells and the cell biology of infection with intracellular pathogens has increased dramatically in recent years. In this review, we discuss the cell biology of the host-microbe interaction for four intracellular pathogens: Chlamydia spp., Legionella pneumophila, Mycobacterium spp., and the protozoan parasite Toxoplasma gondii. All of these organisms reside in vacuoles inside cells that have restricted fusion with host organelles of the endocytic cascade. Despite this restricted fusion, the vacuoles surrounding each pathogen display novel interactions with other host cell organelles. In addition to the effect of infection on host membrane traffic, we focus on these novel interactions and relate them where possible to nutrient acquisition by the intracellular organisms.
KW - Chlamydia
KW - Legionella
KW - Mycobacterium
KW - Toxoplasma
UR - http://www.scopus.com/inward/record.url?scp=0030792813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030792813&partnerID=8YFLogxK
U2 - 10.1146/annurev.micro.51.1.415
DO - 10.1146/annurev.micro.51.1.415
M3 - Review article
C2 - 9343356
AN - SCOPUS:0030792813
SN - 0066-4227
VL - 51
SP - 415
EP - 462
JO - Annual Review of Microbiology
JF - Annual Review of Microbiology
ER -