Safety and tolerability of regadenoson CMR

Kim Lien Nguyen, W. Patricia Bandettini, Sujata Shanbhag, Steve W. Leung, Joel R. Wilson, Andrew E. Arai

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Aims Knowledge of adverse events associated with regadenoson perfusion cardiac magnetic resonance (CMR) and patient tolerability has implications for patient safety and staff training.We sought to assess the safety and tolerability of regadenoson stress CMR. Materials and methods A group of 728 consecutive patients (median age 58, 44% female) and 25 normal volunteers (median age 21, 24% female) were recruited fromAugust 2009 to March 2012 using a prospective, cross-sectional study design. Subjectswere stressed using fixed-dose regadenoson and imaged using a 1.5T MRI scanner. Symptoms and adverse events including death, myocardial infarction (MI), ventricular tachycardia (VT)/ventricular fibrillation (VF), hospitalization, arrhythmias, and haemodynamic stability were assessed. Results There were no occurrences of death, MI, VT/VF, high-grade atrioventricular block, or stress-induced atrial fibrillation. Notable adverse events included one case of bronchospasm and one case of heart failure exacerbation resulting in hospitalization. The most common symptoms in patients were dyspnoea (30%, n = 217), chest discomfort (27%, n = 200), and headache (15%, n = 111). Therewas minimal change between baseline and peak systolic and diastolic blood pressure in both patients and volunteers (P > 0.05).Ablunted heart rate response to regadenosonwas noted in patients with body mass index (BMI) ≥30 kg/m2 (P < 0.001), and diabetes (P = 0.001). Conclusions Regadenoson CMR is well tolerated and can be performed safely with few adverse events.

Original languageEnglish
Pages (from-to)753-760
Number of pages8
JournalEuropean Heart Journal Cardiovascular Imaging
Issue number7
StatePublished - Jul 2014


  • Cardiovascular MRI
  • Coronary artery disease
  • Myocardial perfusion
  • Perfusion imaging
  • Regadenoson
  • Vasodilator agents

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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