Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine

Ryan L. Vander Veen; Alan T. Loynachan; Mark A. Mogler; Brandon J. Russell; D. L.Hank Harris; Kurt I. Kamrud

doi:10.1016/j.vaccine.2012.01.030

Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine

Ryan L. Vander Veen, Alan T. Loynachan, Mark A. Mogler, Brandon J. Russell, D. L.Hank Harris, Kurt I. Kamrud

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different animal studies. Studies done in both the intended host (pigs) and non-host (mice) species demonstrated that the RP vaccine is not shed or spread by vaccinated animals to comingled cohorts, nor does it revert to virulence following vaccination. In addition, vaccinated pigs develop both specific humoral and IFN-γ immune responses, and young pigs are protected against homologous influenza virus challenge.

Original language	English
Pages (from-to)	1944-1950
Number of pages	7
Journal	Vaccine
Volume	30
Issue number	11
DOIs	https://doi.org/10.1016/j.vaccine.2012.01.030
State	Published - Mar 2 2012

Keywords

Alphavirus replicon
Hemagglutinin (HA)
Safety
Swine
Swine influenza virus (SIV)
Vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology (all)
Veterinary (all)
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2012.01.030

Cite this

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title = "Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine",

abstract = "A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different animal studies. Studies done in both the intended host (pigs) and non-host (mice) species demonstrated that the RP vaccine is not shed or spread by vaccinated animals to comingled cohorts, nor does it revert to virulence following vaccination. In addition, vaccinated pigs develop both specific humoral and IFN-γ immune responses, and young pigs are protected against homologous influenza virus challenge.",

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AU - Vander Veen, Ryan L.

AU - Loynachan, Alan T.

AU - Mogler, Mark A.

AU - Russell, Brandon J.

AU - Harris, D. L.Hank

AU - Kamrud, Kurt I.

PY - 2012/3/2

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AB - A single-cycle, propagation-defective replicon particle (RP) vaccine expressing a swine influenza virus hemagglutinin (HA) gene was constructed and evaluated in several different animal studies. Studies done in both the intended host (pigs) and non-host (mice) species demonstrated that the RP vaccine is not shed or spread by vaccinated animals to comingled cohorts, nor does it revert to virulence following vaccination. In addition, vaccinated pigs develop both specific humoral and IFN-γ immune responses, and young pigs are protected against homologous influenza virus challenge.

KW - Alphavirus replicon

KW - Hemagglutinin (HA)

KW - Safety

KW - Swine

KW - Swine influenza virus (SIV)

KW - Vaccine

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VL - 30

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Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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