Safety, tolerability and subject-rated effects of acute intranasal cocaine administration during atomoxetine maintenance

William W. Stoops; John W. Blackburn; David A. Hudson; Lon R. Hays; Craig R. Rush

doi:10.1016/j.drugalcdep.2007.07.005

Safety, tolerability and subject-rated effects of acute intranasal cocaine administration during atomoxetine maintenance

William W. Stoops
, John W. Blackburn
, David A. Hudson
, Lon R. Hays
, Craig R. Rush

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The results of recent research indicate that agonist replacement may be a viable option in the treatment of cocaine dependence. For example, d-amphetamine and modafinil have shown promise in managing cocaine dependence in preliminary clinical trials. The aim of this study was to determine the physiological and subject-rated effects of acute intranasal cocaine doses during chronic atomoxetine treatment. Atomoxetine was chosen because it produces pharmacological and subject-rated effects similar to those of prototypical stimulants and thus may also be a viable agonist replacement therapy. To this end, seven cocaine-dependent subjects were maintained on doses of atomoxetine (0 mg [lead in], 5, 10, 20 and 0 mg [washout], four times daily) for 3-5 days prior to completing experimental sessions in which ascending doses of intranasal cocaine (4, 20, 40 and 60 mg) were administered. Cocaine produced prototypical cardiovascular and subject-rated effects. Atomoxetine attenuated the systolic pressure increasing effects and enhanced the heart rate increasing effects of cocaine, but was otherwise devoid of effects. These results indicate that cocaine is well tolerated during atomoxetine maintenance. Further research is needed to better determine the effects of atomoxetine and cocaine combinations.

Original language	English
Pages (from-to)	282-285
Number of pages	4
Journal	Drug and Alcohol Dependence
Volume	92
Issue number	1-3
DOIs	https://doi.org/10.1016/j.drugalcdep.2007.07.005
State	Published - Jan 1 2008

Bibliographical note

Funding Information:
Acknowledgement of Funding Source: This research is supported by NIDA Grant R01 DA 021155 and NCRR Grant M01 RR02602. The NIDA and NCRR had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.

Funding

Acknowledgement of Funding Source: This research is supported by NIDA Grant R01 DA 021155 and NCRR Grant M01 RR02602. The NIDA and NCRR had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.

Funders	Funder number
National Institute on Drug Abuse	R01 DA 021155
National Center for Research Resources	M01RR002602

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Atomoxetine
Cocaine
Humans
Pharmacotherapy
Physiological effects

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

Access to Document

10.1016/j.drugalcdep.2007.07.005

Cite this

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title = "Safety, tolerability and subject-rated effects of acute intranasal cocaine administration during atomoxetine maintenance",

abstract = "The results of recent research indicate that agonist replacement may be a viable option in the treatment of cocaine dependence. For example, d-amphetamine and modafinil have shown promise in managing cocaine dependence in preliminary clinical trials. The aim of this study was to determine the physiological and subject-rated effects of acute intranasal cocaine doses during chronic atomoxetine treatment. Atomoxetine was chosen because it produces pharmacological and subject-rated effects similar to those of prototypical stimulants and thus may also be a viable agonist replacement therapy. To this end, seven cocaine-dependent subjects were maintained on doses of atomoxetine (0 mg [lead in], 5, 10, 20 and 0 mg [washout], four times daily) for 3-5 days prior to completing experimental sessions in which ascending doses of intranasal cocaine (4, 20, 40 and 60 mg) were administered. Cocaine produced prototypical cardiovascular and subject-rated effects. Atomoxetine attenuated the systolic pressure increasing effects and enhanced the heart rate increasing effects of cocaine, but was otherwise devoid of effects. These results indicate that cocaine is well tolerated during atomoxetine maintenance. Further research is needed to better determine the effects of atomoxetine and cocaine combinations.",

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Safety, tolerability and subject-rated effects of acute intranasal cocaine administration during atomoxetine maintenance

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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