Salivary biomarkers for discriminating periodontitis in the presence of diabetes

Craig S. Miller, Xiuhua Ding, Dolph R. Dawson, Jeffrey L. Ebersole

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Aim: Salivary biomarkers can help in assessment of periodontitis; however, concentrations may be altered in the presence of diabetes. Hence, the ability of salivary biomarkers to discriminate periodontally healthy type II diabetics (T2DM) from T2DM who have periodontitis was examined. Methods: Ninety-two participants (29 with T2DM with chronic periodontitis, DWP; 32 T2DM without chronic periodontitis, DWoP; and 31 Not Periodontitis, NP) provided saliva and clinical parameters of periodontal health were recorded. Salivary concentrations of interleukin (IL)-1β, IL-6, matrix metalloproteinase-8 (MMP-8), macrophage inflammatory protein-1α (MIP-1α), adiponectin and resistin were measured by immunoassay. Results: Salivary analyte concentrations for IL-1β, MMP-8 and resistin correlated with clinical parameters of periodontitis, with MMP-8 demonstrating the strongest positive correlation with PD ≥5 mm (p < 0.0001). Periodontal health was reflected in salivary analyte concentrations by group, with concentrations of IL-1β and MMP-8 showing significant associations with periodontitis (p ≤ 0.04) that increased in concentration from health to DWoP to DWP. Odds ratio (OR) analyses showed that MMP-8 discriminated periodontitis from NP (OR of 8.12; 95% CI: 1.01–65.33; p = 0.03) and in the presence of T2DM (DWP vs DWoP, OR = 5.09; 95% CI: 1.24–20.92; p = 0.03). Conclusion: Salivary MMP-8 and IL-1β discriminate periodontitis in T2DM.

Original languageEnglish
Pages (from-to)216-225
Number of pages10
JournalJournal of Clinical Periodontology
Issue number2
StatePublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


  • biological markers
  • diabetes
  • metalloproteases
  • periodontitis
  • saliva

ASJC Scopus subject areas

  • Periodontics


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