Salivary biomarkers of existing periodontal disease: A cross-sectional study

Cralg S. Miller, Charles P. King, M. Chris Langub, Richard J. Kryscio, Mark V. Thomas

Research output: Contribution to journalArticlepeer-review

279 Scopus citations


Background. The authors conducted a study to determine if salivary biomarkers specific for three aspects of periodontitis-inflammation, collagen degradation and bone turnover-correlate with clinical features of periodontal disease. Method. The relationship between periodontal disease and the levels of interleukin-1 beta (IL-1β), matrix metalloproteinase (MMP)-8, and osteoprotegerin (OPG) in whole saliva of 57 adults (28 "case" subjects with moderate-to-severe periodontal disease and 29 healthy control subjects) was examined in a case-control trial. Result. Mean levels of IL-1β and MMP-8 in saliva were significantly higher in case subjects than in controls. Both analytes correlated with periodontal indexes, whereas, after adjustment for confounders, OPG did not. Elevated salivary levels of MMP-8 or IL-1β (more than two standard deviations above the mean of the controls) significantly increased the risk of periodontal disease (odds ratios in the 11.3-15.4 range). Combined elevated salivary levels of MMP-8 and EL-1β increased the risk of experiencing periodontal disease 45-fold, and elevations in all three biomarkers correlated with individual clinical parameters indicative of periodontal disease. Conclusion. Salivary levels of MMP-8 and IL-1β appear to serve as biomarkers of periodontitis. Clinical Implication. Qualitative changes in the composition of salivary biomarkers could have significance in the diagnosis and treatment of periodontal disease.

Original languageEnglish
Pages (from-to)322-329
Number of pages8
JournalJournal of the American Dental Association
Issue number3
StatePublished - Mar 2006


  • Biomarkers
  • Interieukin-1 beta
  • Matrix metalloproteinase
  • Periodontal disease
  • Saliva

ASJC Scopus subject areas

  • General Dentistry


Dive into the research topics of 'Salivary biomarkers of existing periodontal disease: A cross-sectional study'. Together they form a unique fingerprint.

Cite this