Salivary monitoring of antiepileptic drugs

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Therapeutic drug monitoring is widely used in the anticonvulsant treatment of persons with epilepsy. Most monitoring uses serum, but many anticonvulsant drugs can as easily be monitored using saliva, including phenobarbital, phenytoin, carbamazepine, lamotrigine, oxcarbazepine, topiramate, levetiracetam, and gabapentin. For highly protein-bound medications such as phenobarbital, phenytoin, and carbamazepine, saliva has the advantage of providing an approximation of the serum free level, the free level presumably being the active moiety. Salivary therapeutic drug monitoring offers a number of advantages over serum therapeutic drug monitoring, including lack of pain, lower cost, and wide potential acceptability by patients and physicians. It has the potential to open new approaches to treatment with strategic at-home monitoring at the time a seizure or adverse event occurs and to allow the collection of cohort-based, pharmacokinetic, and pharmcodynamic data for populations of persons of varying ages and with different medical conditions who require anticonvulsant medications.

Original languageEnglish
Pages (from-to)147-157
Number of pages11
JournalJournal of Pharmacy Practice
Issue number2
StatePublished - Apr 2007


  • Anticonvulsant medication
  • Epilepsy
  • Saliva

ASJC Scopus subject areas

  • Pharmacology (medical)


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