Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum

Wayne W. Harding, Kevin Tidgewell, Matthew Schmidt, Kushal Shah, Christina M. Dersch, John Snyder, Damon Parrish, Jeffrey R. Deschamps, Richard B. Rothman, Thomas E. Prisinzano

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

(Chemical Equation Presented) Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including 1H and 13C NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.

Original languageEnglish
Pages (from-to)3017-3020
Number of pages4
JournalOrganic Letters
Volume7
Issue number14
DOIs
StatePublished - Jul 7 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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