Abstract
In this paper, an exact variance of the one-sample log-rank test statistic is derived under the alternative hypothesis, and a sample size formula is proposed based on the derived exact variance. Simulation results showed that the proposed sample size formula provides adequate power to design a study to compare the survival of a single sample with that of a standard population.
| Original language | English |
|---|---|
| Pages (from-to) | 26-33 |
| Number of pages | 8 |
| Journal | Pharmaceutical Statistics |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
Bibliographical note
Publisher Copyright:Copyright © 2014 JohnWiley & Sons, Ltd.
Keywords
- Counting process
- One-sample log-rank test
- Sample size formula
- Standard population
- Time to event
ASJC Scopus subject areas
- Statistics and Probability
- Pharmacology
- Pharmacology (medical)