Abstract
In this paper, an exact variance of the one-sample log-rank test statistic is derived under the alternative hypothesis, and a sample size formula is proposed based on the derived exact variance. Simulation results showed that the proposed sample size formula provides adequate power to design a study to compare the survival of a single sample with that of a standard population.
Original language | English |
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Pages (from-to) | 26-33 |
Number of pages | 8 |
Journal | Pharmaceutical Statistics |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2015 |
Bibliographical note
Publisher Copyright:Copyright © 2014 JohnWiley & Sons, Ltd.
Keywords
- Counting process
- One-sample log-rank test
- Sample size formula
- Standard population
- Time to event
ASJC Scopus subject areas
- Statistics and Probability
- Pharmacology
- Pharmacology (medical)