Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages

Michael J. Cavnar; Ronald P. DeMatteo

doi:10.4161/onci.28463

Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages

Michael J. Cavnar, Ronald P. DeMatteo

Surgery

Research output: Contribution to journal › Comment/debate

5 Scopus citations

Abstract

In gastrointestinal stromal tumor (GIST ), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.

Original language	English
Article number	e28463
Journal	OncoImmunology
Volume	3
Issue number	4
DOIs	https://doi.org/10.4161/onci.28463
State	Published - 2014

Keywords

C/EBPβ
CSF1R
Gastrointestinal stromal tumor
Macrophage
Tumor-associated macrophage

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.28463

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title = "Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages",

abstract = "In gastrointestinal stromal tumor (GIST ), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.",

keywords = "C/EBPβ, CSF1R, Gastrointestinal stromal tumor, Macrophage, Tumor-associated macrophage",

author = "Cavnar, {Michael J.} and DeMatteo, {Ronald P.}",

year = "2014",

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T1 - Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages

AU - Cavnar, Michael J.

AU - DeMatteo, Ronald P.

PY - 2014

Y1 - 2014

N2 - In gastrointestinal stromal tumor (GIST ), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.

AB - In gastrointestinal stromal tumor (GIST ), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.

KW - C/EBPβ

KW - CSF1R

KW - Gastrointestinal stromal tumor

KW - Macrophage

KW - Tumor-associated macrophage

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U2 - 10.4161/onci.28463

DO - 10.4161/onci.28463

M3 - Comment/debate

AN - SCOPUS:84902595569

SN - 2162-4011

VL - 3

JO - OncoImmunology

JF - OncoImmunology

IS - 4

M1 - e28463

ER -

Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages

Abstract

Keywords

ASJC Scopus subject areas

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