TY - JOUR
T1 - Satellite cell dynamics during skeletal muscle hypertrophy
AU - Saliu, Tolulope P.
AU - Goh, Jensen
AU - Kang, Gyumin
AU - Burke, Benjamin I.
AU - Ismaeel, Ahmed
AU - McCarthy, John J.
N1 - Publisher Copyright:
© 2024 The Author(s).
PY - 2024/8
Y1 - 2024/8
N2 - Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.
AB - Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.
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U2 - 10.1042/BST20240201
DO - 10.1042/BST20240201
M3 - Review article
C2 - 39136196
AN - SCOPUS:85202789892
SN - 0300-5127
VL - 52
SP - 1921
EP - 1926
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
IS - 4
ER -