Satellite cell dynamics during skeletal muscle hypertrophy

Tolulope P. Saliu, Jensen Goh, Gyumin Kang, Benjamin I. Burke, Ahmed Ismaeel, John J. McCarthy

Research output: Contribution to journalReview articlepeer-review

Abstract

Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.

Original languageEnglish
Pages (from-to)1921-1926
Number of pages6
JournalBiochemical Society Transactions
Volume52
Issue number4
DOIs
StatePublished - Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s).

ASJC Scopus subject areas

  • Biochemistry

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