Satellite cell dynamics during skeletal muscle hypertrophy

Tolulope P. Saliu; Jensen Goh; Gyumin Kang; Benjamin I. Burke; Ahmed Ismaeel; John J. McCarthy

doi:10.1042/BST20240201

Satellite cell dynamics during skeletal muscle hypertrophy

Tolulope P. Saliu, Jensen Goh, Gyumin Kang, Benjamin I. Burke, Ahmed Ismaeel, John J. McCarthy

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.

Original language	English
Pages (from-to)	1921-1926
Number of pages	6
Journal	Biochemical Society Transactions
Volume	52
Issue number	4
DOIs	https://doi.org/10.1042/BST20240201
State	Published - Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s).

Funding

This work was supported by National Institutes of Health grants from the National Institute on Aging (AG069909) to J.J.M.

Funders	Funder number
National Institutes of Health (NIH)
National Institute on Aging	AG069909
National Institute on Aging

ASJC Scopus subject areas

Biochemistry

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10.1042/BST20240201

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title = "Satellite cell dynamics during skeletal muscle hypertrophy",

abstract = "Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.",

author = "Saliu, \{Tolulope P.\} and Jensen Goh and Gyumin Kang and Burke, \{Benjamin I.\} and Ahmed Ismaeel and McCarthy, \{John J.\}",

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doi = "10.1042/BST20240201",

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T1 - Satellite cell dynamics during skeletal muscle hypertrophy

AU - Saliu, Tolulope P.

AU - Goh, Jensen

AU - Kang, Gyumin

AU - Burke, Benjamin I.

AU - Ismaeel, Ahmed

AU - McCarthy, John J.

PY - 2024/8

Y1 - 2024/8

N2 - Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.

AB - Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.

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DO - 10.1042/BST20240201

M3 - Review article

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SN - 0300-5127

VL - 52

SP - 1921

EP - 1926

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

Satellite cell dynamics during skeletal muscle hypertrophy

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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