Scaffold composition and biological relevance of screening libraries

Anang A. Shelat; R. Kiplin Guy

doi:10.1038/nchembio0807-442

Scaffold composition and biological relevance of screening libraries

Anang A. Shelat, R. Kiplin Guy

Research output: Contribution to journal › Review article › peer-review

142 Scopus citations

Abstract

The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.

Original language	English
Pages (from-to)	442-446
Number of pages	5
Journal	Nature Chemical Biology
Volume	3
Issue number	8
DOIs	https://doi.org/10.1038/nchembio0807-442
State	Published - Aug 2007

Bibliographical note

Funding Information:
This? work? was? supported? by? the? American? Lebanese? Syrian? Associated? Charities? (ALSAC)? and? St.? Jude? Children’s? Research? Hospital? (SJCRH).

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nchembio0807-442

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title = "Scaffold composition and biological relevance of screening libraries",

abstract = "The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.",

author = "Shelat, {Anang A.} and Guy, {R. Kiplin}",

note = "Funding Information: This? work? was? supported? by? the? American? Lebanese? Syrian? Associated? Charities? (ALSAC)? and? St.? Jude? Children{\textquoteright}s? Research? Hospital? (SJCRH).",

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AU - Guy, R. Kiplin

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Scaffold composition and biological relevance of screening libraries

Abstract

Bibliographical note

ASJC Scopus subject areas

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