Scaffold composition and biological relevance of screening libraries

Anang A. Shelat, R. Kiplin Guy

Research output: Contribution to journalReview articlepeer-review

142 Scopus citations


The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.

Original languageEnglish
Pages (from-to)442-446
Number of pages5
JournalNature Chemical Biology
Issue number8
StatePublished - Aug 2007

Bibliographical note

Funding Information:
This? work? was? supported? by? the? American? Lebanese? Syrian? Associated? Charities? (ALSAC)? and? St.? Jude? Children’s? Research? Hospital? (SJCRH).

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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