Abstract
We report a novel approach for the accurate measurement of glucose absorption in turbid media using a spectrally resolved reflectance setup. Our proposed reflectance setup with specialized variable source-detector separations enables scattering-independent absorption measurement, which is critical to in vivo long-term glucose concentration monitoring. Starting from the first-order approximation of the radiative transfer equation (RTE), we developed a scattering-independent glucose absorption measurement method and then evaluated this approach by Monte Carlo simulations as well as tissue-mimicking phantom studies in which glucose concentration was accurately measured. Our study demonstrates the potential of our proposed scattering-independent absorption measurement technique as an effective tool to quantify glucose levels in turbid media, which is an important step towards future in vivo long-term glucose concentration monitoring in human subjects.
Original language | English |
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Article number | #344745 |
Pages (from-to) | 5903-5914 |
Number of pages | 12 |
Journal | Biomedical Optics Express |
Volume | 9 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2018 |
Bibliographical note
Publisher Copyright:© 2018 Optical Society of America.
ASJC Scopus subject areas
- Biotechnology
- Atomic and Molecular Physics, and Optics