Scattering-independent glucose absorption measurement using a spectrally resolved reflectance setup with specialized variable source-detector separations

Jin Liu, Caigang Zhu, Jingying Jiang, Kexin Xu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We report a novel approach for the accurate measurement of glucose absorption in turbid media using a spectrally resolved reflectance setup. Our proposed reflectance setup with specialized variable source-detector separations enables scattering-independent absorption measurement, which is critical to in vivo long-term glucose concentration monitoring. Starting from the first-order approximation of the radiative transfer equation (RTE), we developed a scattering-independent glucose absorption measurement method and then evaluated this approach by Monte Carlo simulations as well as tissue-mimicking phantom studies in which glucose concentration was accurately measured. Our study demonstrates the potential of our proposed scattering-independent absorption measurement technique as an effective tool to quantify glucose levels in turbid media, which is an important step towards future in vivo long-term glucose concentration monitoring in human subjects.

Original languageEnglish
Article number#344745
Pages (from-to)5903-5914
Number of pages12
JournalBiomedical Optics Express
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2018

Bibliographical note

Publisher Copyright:
© 2018 Optical Society of America.

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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