Scavenger receptor BI and cholesterol trafficking

David L. Williams, Margery A. Connelly, Ryan E. Temel, Snehasikta Swarnakar, Michael C. Phillips, Margarita De la Llera-Moya, George H. Rothblat

Research output: Contribution to journalReview articlepeer-review

173 Scopus citations


Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.

Original languageEnglish
Pages (from-to)329-339
Number of pages11
JournalCurrent Opinion in Lipidology
Issue number4
StatePublished - 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology


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