TY - JOUR
T1 - Scavenger receptor BI and cholesterol trafficking
AU - Williams, David L.
AU - Connelly, Margery A.
AU - Temel, Ryan E.
AU - Swarnakar, Snehasikta
AU - Phillips, Michael C.
AU - De la Llera-Moya, Margarita
AU - Rothblat, George H.
PY - 1999
Y1 - 1999
N2 - Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.
AB - Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.
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U2 - 10.1097/00041433-199908000-00007
DO - 10.1097/00041433-199908000-00007
M3 - Review article
C2 - 10482136
AN - SCOPUS:0032822860
SN - 0957-9672
VL - 10
SP - 329
EP - 339
JO - Current Opinion in Lipidology
JF - Current Opinion in Lipidology
IS - 4
ER -
