Scavenger receptor BI and cholesterol trafficking

David L. Williams; Margery A. Connelly; Ryan E. Temel; Snehasikta Swarnakar; Michael C. Phillips; Margarita De la Llera-Moya; George H. Rothblat

doi:10.1097/00041433-199908000-00007

Scavenger receptor BI and cholesterol trafficking

David L. Williams, Margery A. Connelly, Ryan E. Temel, Snehasikta Swarnakar, Michael C. Phillips, Margarita De la Llera-Moya, George H. Rothblat

Physiology

Research output: Contribution to journal › Review article › peer-review

173 Scopus citations

Abstract

Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.

Original language	English
Pages (from-to)	329-339
Number of pages	11
Journal	Current Opinion in Lipidology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1097/00041433-199908000-00007
State	Published - 1999

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Molecular Biology
Genetics
Nutrition and Dietetics
Cardiology and Cardiovascular Medicine
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00041433-199908000-00007

Cite this

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abstract = "Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.",

author = "Williams, {David L.} and Connelly, {Margery A.} and Temel, {Ryan E.} and Snehasikta Swarnakar and Phillips, {Michael C.} and {De la Llera-Moya}, Margarita and Rothblat, {George H.}",

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AU - Williams, David L.

AU - Connelly, Margery A.

AU - Temel, Ryan E.

AU - Swarnakar, Snehasikta

AU - Phillips, Michael C.

AU - De la Llera-Moya, Margarita

AU - Rothblat, George H.

PY - 1999

Y1 - 1999

N2 - Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.

AB - Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.

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AN - SCOPUS:0032822860

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SP - 329

EP - 339

JO - Current Opinion in Lipidology

JF - Current Opinion in Lipidology

IS - 4

ER -

Scavenger receptor BI and cholesterol trafficking

Abstract

ASJC Scopus subject areas

UN SDGs

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