Scavenger receptor class B type I and immune dysfunctions

Zhong Zheng, Junting Ai, Xiang An Li

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

PURPOSE OF REVIEW: To summarize the recent findings about the roles of scavenger receptor class B type I (SR-BI) in immunity and discuss the underlying mechanisms by which SR-BI prevents immune dysfunctions. RECENT FINDINGS: SR-BI is well known as a high-density lipoprotein (HDL) receptor playing key roles in HDL metabolism and in protection against atherosclerosis. Recent studies have indicated that SR-BI is also an essential modulator in immunity. SR-BI deficiency in mice causes immune dysfunctions, including increased atherosclerosis, elevated susceptibility to sepsis, impaired lymphocyte homeostasis, and autoimmune disorders. SR-BI exerts its protective roles through a variety of HDL-dependent and HDL-independent mechanisms. SR-BI is also involved in hepatitis C virus cell entry. A deficiency of SR-BI in humanized mice has been shown to decrease hepatitis C virus infectivity. SUMMARY: SR-BI regulates immunity via multiple mechanisms and its deficiency causes numerous diseases. A comprehensive understanding of the roles of SR-BI in protection against immune dysfunctions may provide a therapeutic target for intervention against its associated diseases.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume21
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • HDL
  • SR-BI
  • atherosclerosis
  • dysfunctions
  • immunity
  • inflammation
  • sepsis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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