Abstract
A prior study in a US state hospital suggested that schizophrenia is more closely associated with tobacco smoking when compared with other severe mental illnesses. This second study, in a neighborhood hospital, tries to (1) replicate that schizophrenia is associated with smoking and heavy smoking, and (2) rule out that this relationship is explained by substance use. The methodology was very similar to the first study. The sample included 588 inpatients. Logistic regression was used to develop models of variables associated with smoking or heavy smoking. The frequency of current smoking for the total, schizophrenic and non-schizophrenic samples were respectively 71, 75, and 55%. The sequence of frequencies from the highest to lowest was the same as in the first study: male schizophrenic patients, male non-schizophrenic patients, female schizophrenic patients and female non-schizophrenic patients. This second study consistently replicated the relationship between schizophrenia and smoking (after correcting for other variables) including history of alcohol and drug abuse or dependence. Only one of two definitions of heavy smoking showed a significant association with schizophrenia. In summary, these two studies suggest that schizophrenia is strongly associated with smoking. Neither substance use, antipsychotics, nor institutionalism can explain this relationship.
| Original language | English |
|---|---|
| Pages (from-to) | 55-65 |
| Number of pages | 11 |
| Journal | Schizophrenia Research |
| Volume | 56 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jul 1 2002 |
Bibliographical note
Funding Information:This study was possible by the collaboration of the staff of the hospital and the support of Albert R. Di Dario, Superintendent of Norristown State Hospital at that time and of Richard Jossiasen PhD, Director of the Clinical Research Center. Jose de Leon's salary is partly supported by the NIH grant MH-51380. Francisco J. Diaz is an Associate Instructor of Statistics at the Universidad Nacional de Colombia. His collaboration in the statistical analyses of this article was supported by a grant from the Kentucky Department of Mental Health and Mental Retardation, the Department of Psychiatry of the University of Kentucky through the University Collaboration Project, and a fellowship from the Department of Statistics of the University of Kentucky.
Funding
This study was possible by the collaboration of the staff of the hospital and the support of Albert R. Di Dario, Superintendent of Norristown State Hospital at that time and of Richard Jossiasen PhD, Director of the Clinical Research Center. Jose de Leon's salary is partly supported by the NIH grant MH-51380. Francisco J. Diaz is an Associate Instructor of Statistics at the Universidad Nacional de Colombia. His collaboration in the statistical analyses of this article was supported by a grant from the Kentucky Department of Mental Health and Mental Retardation, the Department of Psychiatry of the University of Kentucky through the University Collaboration Project, and a fellowship from the Department of Statistics of the University of Kentucky.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | |
| National Institute of Mental Health | R29MH051380 |
| Michigan Department of Mental Health | |
| University of Kentucky |
Keywords
- Logistic regression
- Nicotine
- Nicotine dependence
- Schizophrenia
- Smoking
- Tobacco
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
