Seasonal Variation of Laboratory Animals as a Consideration for Research Reproducibility

Mark A. Suckow, Noé Tirado-Muñiz

Research output: Contribution to journalReview articlepeer-review


Laboratory rodents are generally maintained under standardized conditions in order to control the effects of extrinsic factors on research. However, despite attempts to standardize conditions, variability can nonetheless confound efforts directed toward research reproducibility. Here we explore some of the existing literature on the potential impact of seasonal variability as an extrinsic factor that can potentially impact research results. We discuss the influence of seasonal changes in association with an internal clock mechanism that might account for such variation, noting that the mechanisms and interactions of seasonal and internal time-keeping remain largely undetermined. Finally, we speculate that seasonal changes experienced by personnel who handle animals may influence the animals in ways that result in physiologic and behavioral changes.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalComparative Medicine
Issue number4
StatePublished - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023 American Association for Laboratory Animal Science. All Rights Reserved.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Veterinary


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