Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Daiani C. Savi; Khaled A. Shaaban; Prithiba Mitra; Larissa V. Ponomareva; Jon S. Thorson; Chirlei Glienke; Jürgen Rohr

doi:10.1038/s41429-019-0154-3

Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Daiani C. Savi, Khaled A. Shaaban, Prithiba Mitra, Larissa V. Ponomareva, Jon S. Thorson, Chirlei Glienke, Jürgen Rohr

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.

Original language	English
Pages (from-to)	306-310
Number of pages	5
Journal	Journal of Antibiotics
Volume	72
Issue number	5
DOIs	https://doi.org/10.1038/s41429-019-0154-3
State	Published - May 1 2019

Bibliographical note

Funding Information:
Acknowledgements This work was supported by NIH grants CA 91091, GM 105977 and an Endowed University Professorship in Pharmacy to J.R. This work was also supported by National Institutes of Health grants R24 OD21479 (JST), the University of Kentucky College of Pharmacy, the University of Kentucky Markey Cancer Center and the National Center for Advancing Translational Sciences (UL1TR001998). It was also supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico–Brazil grant 424738/2016-3 and CNPq309971/2016-0 to C.G., and CAPES-Brazil – grant to D.C.S. We thank the College of Pharmacy NMR Center (University of Kentucky) for NMR support.

Publisher Copyright:
© 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41429-019-0154-3

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abstract = "The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.",

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note = "Funding Information: Acknowledgements This work was supported by NIH grants CA 91091, GM 105977 and an Endowed University Professorship in Pharmacy to J.R. This work was also supported by National Institutes of Health grants R24 OD21479 (JST), the University of Kentucky College of Pharmacy, the University of Kentucky Markey Cancer Center and the National Center for Advancing Translational Sciences (UL1TR001998). It was also supported by Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico–Brazil grant 424738/2016-3 and CNPq309971/2016-0 to C.G., and CAPES-Brazil – grant to D.C.S. We thank the College of Pharmacy NMR Center (University of Kentucky) for NMR support. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.",

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Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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