TY - JOUR
T1 - Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa
AU - Savi, Daiani C.
AU - Shaaban, Khaled A.
AU - Mitra, Prithiba
AU - Ponomareva, Larissa V.
AU - Thorson, Jon S.
AU - Glienke, Chirlei
AU - Rohr, Jürgen
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.
AB - The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.
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U2 - 10.1038/s41429-019-0154-3
DO - 10.1038/s41429-019-0154-3
M3 - Article
C2 - 30792517
AN - SCOPUS:85064206589
SN - 0021-8820
VL - 72
SP - 306
EP - 310
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 5
ER -