Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Daiani C. Savi; Khaled A. Shaaban; Prithiba Mitra; Larissa V. Ponomareva; Jon S. Thorson; Chirlei Glienke; Jürgen Rohr

doi:10.1038/s41429-019-0154-3

Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Daiani C. Savi, Khaled A. Shaaban, Prithiba Mitra, Larissa V. Ponomareva, Jon S. Thorson, Chirlei Glienke, Jürgen Rohr

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.

Original language	English
Pages (from-to)	306-310
Number of pages	5
Journal	Journal of Antibiotics
Volume	72
Issue number	5
DOIs	https://doi.org/10.1038/s41429-019-0154-3
State	Published - May 1 2019

Bibliographical note

Publisher Copyright:
© 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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title = "Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa",

abstract = "The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.",

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AU - Savi, Daiani C.

AU - Shaaban, Khaled A.

AU - Mitra, Prithiba

AU - Ponomareva, Larissa V.

AU - Thorson, Jon S.

AU - Glienke, Chirlei

AU - Rohr, Jürgen

PY - 2019/5/1

Y1 - 2019/5/1

N2 - The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.

AB - The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.

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Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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