TY - GEN
T1 - Seizure modulation with applied electric fields in chronically implanted animals
AU - Sunderam, S.
AU - Chernyy, N.
AU - Mason, J.
AU - Peixoto, N.
AU - Weinstein, S. L.
AU - Schiff, S. J.
AU - Gluckman, B. J.
PY - 2006
Y1 - 2006
N2 - Low Frequency (≪100Hz) applied electric fields have been shown to modulate neuronal activity both In Vitro and in acute whole animal studies [1-3], We have been working to apply this technology for seizure control in chronically implanted animals. We have developed electronics for simultaneously recording neural activity while stimulating with low frequency fields. We have observed transient entrainment of spike and wave activity during spontaneous seizures with open loop sinusoidal stimulation with frequencies between 9-15 Hz. This is the first demonstration of low frequency field modulation of neural activity in chronically implanted mammalian brain.
AB - Low Frequency (≪100Hz) applied electric fields have been shown to modulate neuronal activity both In Vitro and in acute whole animal studies [1-3], We have been working to apply this technology for seizure control in chronically implanted animals. We have developed electronics for simultaneously recording neural activity while stimulating with low frequency fields. We have observed transient entrainment of spike and wave activity during spontaneous seizures with open loop sinusoidal stimulation with frequencies between 9-15 Hz. This is the first demonstration of low frequency field modulation of neural activity in chronically implanted mammalian brain.
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UR - http://www.scopus.com/inward/citedby.url?scp=34047163064&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.259454
DO - 10.1109/IEMBS.2006.259454
M3 - Conference contribution
C2 - 17946910
AN - SCOPUS:34047163064
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 1612
EP - 1615
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -