Self-assembly of phospholipid-PEG coating on nanoparticles through dual solvent exchange

Sheng Tong, Sijian Hou, Binbin Ren, Zhilan Zheng, Gang Bao

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


We coated nanoparticles including iron oxide nanoparticles and quantum dots with phospholipid-PEG using the newly developed dual solvent exchange method and demonstrated that, compared with the conventional film hydration method, the coating efficiency and quality of coated nanoparticles can be significantly improved. A better control of surface coating density and the amount of reactive groups on nanoparticle surface is achieved, allowing conjugation of different moieties with desirable surface concentrations, thus facilitating biomedical applications of nanoparticles.

Original languageEnglish
Pages (from-to)3720-3726
Number of pages7
JournalNano Letters
Issue number9
StatePublished - Sep 14 2011


  • Nanoparticle
  • coating
  • phospholipid-PEG
  • solvent exchange

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry (all)
  • Materials Science (all)
  • Condensed Matter Physics
  • Mechanical Engineering


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