@article{955c6824980b4c698f155ba5c91a8bd6,
title = "Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort",
abstract = "Aims: To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer's disease (AD)-type pathological changes. Methods: Clinical and neuropathological data from participants enrolled in a longitudinal study of aging and cognition (n = 649) were analyzed to assess the chronic effects of self-reported head injury. Results: The effect of self-reported head injury on the clinical state depended on the age at assessment: for a 1-year increase in age, the OR for the transition to clinical mild cognitive impairment (MCI) at the next visit for participants with a history of head injury was 1.21 and 1.34 for the transition from MCI to dementia. Without respect to age, head injury increased the odds of mortality (OR = 1.54). Moreover, it increased the odds of a pathological diagnosis of AD for men (OR = 1.47) but not women (OR = 1.18). Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without. Conclusions: Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes.",
keywords = "Alzheimer's disease, Cognition, Dementia, Head injury, Neuropathology",
author = "Abner, \{Erin L.\} and Nelson, \{Peter T.\} and Schmitt, \{Frederick A.\} and Browning, \{Steven R.\} and Fardo, \{David W.\} and Lijie Wan and Jicha, \{Gregory A.\} and Cooper, \{Gregory E.\} and Smith, \{Charles D.\} and Caban-Holt, \{Allison M.\} and \{Van Eldik\}, \{Linda J.\} and Kryscio, \{Richard J.\}",
year = "2014",
month = jun,
doi = "10.1159/000355478",
language = "English",
volume = "37",
pages = "294--306",
number = "5-6",
}
