Self-Reported Sleep Apnea and Dementia Risk: Findings from the Prevention of Alzheimer's Disease with Vitamin E and Selenium Trial

Xiuhua Ding, Richard J. Kryscio, Joshua Turner, Gregory A. Jicha, Gregory Cooper, Allison Caban-Holt, Frederick A. Schmitt, Erin L. Abner

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objectives: To investigate the association between baseline sleep apnea and risk of incident dementia in the Prevention of Alzheimer's Disease with Vitamin E and Selenium (PREADViSE) study and to explore whether the association depends on apolipoprotein E (APOE) ɛ4 allele status. Design: Secondary analysis based on data collected during PREADViSE. Setting: Participants were assessed at 128 local clinical study sites during the clinical trial phase and later were followed by telephone from a centralized location. Participants: Men enrolled in PREADViSE (without dementia or other active neurological conditions that affect cognition such as major psychiatric disorders, including depression; N = 7,547). Measurements: Participants were interviewed at baseline for sleep apnea. The Memory Impairment Screen (MIS) was administered to each participant annually. Subjects who failed this initial screen were tested with secondary screening tests. Medical history and medication use were determined, and the AD8 dementia screening instrument was used. Results: The effect of self-reported sleep apnea on dementia risk depended on APOE ɛ4 status. When the allele was absent, baseline self-reported sleep apnea was associated with a 66% higher risk of developing dementia (95% confidence interval = 2–170%), whereas self-reported sleep apnea conferred no additional risk for participants with an ɛ4 allele. Conclusion: Sleep apnea may increase risk of dementia in the absence of APOE ɛ4. This may help inform prevention strategies for dementia or AD in older men with sleep apnea. Registration: PREADViSE is registered at NCT00040378.

Original languageEnglish
Pages (from-to)2472-2478
Number of pages7
JournalJournal of the American Geriatrics Society
Issue number12
StatePublished - Dec 1 2016

Bibliographical note

Funding Information:
Conflict of Interest: The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any other kind of personal conflicts with this paper. PREADViSE (NCT00040378) is supported by National Institute on Aging (NIA) R01 AG019421. Additional support for the current study comes from NIA R01 AG038651 and P30 AG028383. SELECT was supported by National Cancer Institute Grants CA37429 and UM1 CA182883. Author Contributions: Ding: study design, data analyses, drafting and revision of manuscript. Kryscio, Caban-Holt: design of PREADViSE, revision of manuscript. Turner: study design, data collection, revision of manuscript. Jicha, Cooper: evaluation of participants for dementia, revision of manuscript. Schmitt: design of PREADViSE, evaluation of participants for dementia, revision of manuscript. Abner: study design, supervision of analyses, drafting and revision of manuscript. Sponsor's Role: NCI was involved in the design of SELECT. Otherwise, the sponsors had no role in the design or conduct of the current study; collection, analysis, or interpretation of data; or preparation, review, or approval of the manuscript.

Publisher Copyright:
© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society


  • APOE
  • dementia
  • self-reported sleep apnea

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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