Semiautomated thermal lesion segmentation for three-dimensional elastographic imaging

U. Techavipoo, T. Varghese, J. A. Zagzebski, Q. Chen, W. Liu

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Several studies have demonstrated that lesion volumes computed from multiple planar slices through the region-of-interest (ROI) are more accurate than volumes estimated assuming simple shapes and incorporating single or orthogonal diameter estimates. However, manual delineation of boundaries on multiple planar 2-D images is tedious and labor-intensive. Automatic extraction of lesion boundaries is, therefore, attractive and imperative to remove subjectivity and reduce assessment time. This paper presents a semiautomated segmentation algorithm for thermal lesions on 3-D elastographic data to obtain both area and volume information. The semiautomated segmentation algorithm is based on thresholding and morphologic opening of both 2-D and 3-D elastographic data. Results obtained on 44 thermal lesions imaged in vitro using elastography were compared to manual delineation of both elastographic and pathology images. Results obtained using semiautomated segmentation demonstrate a close correspondence with manual delineation results. However, area and volume estimates obtained using both manual and semiautomated segmentation of lesions seen on elastograms slightly underestimate areas and volumes measured from pathology. (E-mail:

Original languageEnglish
Pages (from-to)655-664
Number of pages10
JournalUltrasound in Medicine and Biology
Issue number5
StatePublished - May 2004

Bibliographical note

Funding Information:
The authors thank Larry Whitesell and Ms. Jennifer Buck for providing liver tissue samples used for the experimental work. This work was supported in part by the Whitaker Foundation (grant RG-02-0457) and start-up grant funds awarded to Dr. Varghese from the Department of Medical Physics, Medical School and Graduate School at the University of Wisconsin-Madison.


  • 3-D ultrasound imaging
  • Elasticity
  • Elastogram
  • Elastography
  • Imaging
  • Radiofrequency ablation
  • Segmentation
  • Strain
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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