Sensitivity of left ventricular mechanics to myofiber architecture: A finite element study

Amir Nikou, Robert C. Gorman, Jonathan F. Wenk

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The goal of this study was to investigate the sensitivity of computational models of the heart to their incorporated myofiber architecture during diastole. This architecture plays a critical role in the mechanical and electrical function of the heart and changes after myocardial tissue remodeling, which is associated with some of the most common heart diseases. In this study, a left ventricular finite element model of the porcine heart was created using magnetic resonance imaging, which represents the in vivo geometry. Various myofiber architectures were assigned to the finite element mesh, in the form of fiber and sheet angles. A structural-based material law was used to model the behavior of passive myocardium and its parameters were estimated using measured in vivo strains and cavity volume from magnetic resonance imaging. The final results showed noticeable sensitivity of the stress distribution to both the fiber and sheet angle distributions. This implies that a structural-based material law that takes into account the effect of both fiber and sheet angle distributions should be used. The results also show that although the simulation results improve using available data from histological studies of myocardial structure, the need for individualized myofiber architecture data is crucial.

Original languageEnglish
Pages (from-to)594-598
Number of pages5
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Issue number6
StatePublished - Jun 2016

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the National Institutes of Health grant R01 HL063954 (R. Gorman) and by a grant from the American Heart Association 14BGIA18850020 (J. Wenk).

Publisher Copyright:
© 2016 IMechE.


  • Myofiber architecture
  • numerical modeling
  • passive myocardium
  • stress distribution

ASJC Scopus subject areas

  • Mechanical Engineering


Dive into the research topics of 'Sensitivity of left ventricular mechanics to myofiber architecture: A finite element study'. Together they form a unique fingerprint.

Cite this