Sequential release of multiple drugs from flexible drug delivery films

Cheryl L. Jennings, Ellis K. Perry, Thomas D. Dziubla, David A. Puleo

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with the increasing plasticizer content. Release profiles can be tailored by order of layers, plasticizer concentration, and drug loading, making CAP–Pluronic an appealing system for inhibiting scar tissue formation.

Original languageEnglish
Pages (from-to)569-576
Number of pages8
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume66
Issue number11
DOIs
StatePublished - Jul 24 2017

Bibliographical note

Publisher Copyright:
© 2017 Taylor & Francis.

Keywords

  • Cytotoxicity
  • drug delivery
  • mechanical properties
  • plasticizer
  • sequential drug release

ASJC Scopus subject areas

  • Analytical Chemistry
  • General Chemical Engineering
  • Polymers and Plastics

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