Sequential release of multiple drugs from flexible drug delivery films

Cheryl L. Jennings; Ellis K. Perry; Thomas D. Dziubla; David A. Puleo

doi:10.1080/00914037.2016.1252352

Sequential release of multiple drugs from flexible drug delivery films

Cheryl L. Jennings, Ellis K. Perry, Thomas D. Dziubla, David A. Puleo

Chemical and Materials Engineering

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with the increasing plasticizer content. Release profiles can be tailored by order of layers, plasticizer concentration, and drug loading, making CAP–Pluronic an appealing system for inhibiting scar tissue formation.

Original language	English
Pages (from-to)	569-576
Number of pages	8
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	66
Issue number	11
DOIs	https://doi.org/10.1080/00914037.2016.1252352
State	Published - Jul 24 2017

Bibliographical note

Publisher Copyright:
© 2017 Taylor & Francis.

Keywords

Cytotoxicity
drug delivery
mechanical properties
plasticizer
sequential drug release

ASJC Scopus subject areas

Analytical Chemistry
Chemical Engineering (all)
Polymers and Plastics

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10.1080/00914037.2016.1252352

Cite this

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title = "Sequential release of multiple drugs from flexible drug delivery films",

abstract = "Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with the increasing plasticizer content. Release profiles can be tailored by order of layers, plasticizer concentration, and drug loading, making CAP–Pluronic an appealing system for inhibiting scar tissue formation.",

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AU - Perry, Ellis K.

AU - Dziubla, Thomas D.

AU - Puleo, David A.

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AB - Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with the increasing plasticizer content. Release profiles can be tailored by order of layers, plasticizer concentration, and drug loading, making CAP–Pluronic an appealing system for inhibiting scar tissue formation.

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Sequential release of multiple drugs from flexible drug delivery films

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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