Serum amyloid A in atherosclerosis

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Purpose of Review: Serum amyloid A (SAA) is a family of acute-phase proteins which are shown to correlate with cardiovascular disease, but whether this SAA contributes causally to atherosclerosis development or reflects underlying disease or risk factors remains unclear. Recent Findings: SAA has been detected within atherosclerotic lesions and within adipose tissue where it is hypothesized that it may play a contributory role in disease development. In the acute-phase response SAA is synthesized by the liver and transported primarily in association with HDL. However, there is a growing literature suggesting that localized synthesis of SAA within the vasculature, or adipose tissue, may play a distinct role in disease development. Furthermore, SAA can be found in association with apoB-containing lipoproteins, in which its biological activity may be different. Summary: This review will discuss recent experimental evidence supporting a causal role of SAA with atherosclerosis.

Original languageEnglish
Pages (from-to)302-307
Number of pages6
JournalCurrent Opinion in Lipidology
Volume22
Issue number4
DOIs
StatePublished - Aug 2011

Keywords

  • HDL
  • cardiovascular disease
  • inflammation
  • obesity
  • proteoglycans

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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