Abstract
Purpose of Review: Serum amyloid A (SAA) is a family of acute-phase proteins which are shown to correlate with cardiovascular disease, but whether this SAA contributes causally to atherosclerosis development or reflects underlying disease or risk factors remains unclear. Recent Findings: SAA has been detected within atherosclerotic lesions and within adipose tissue where it is hypothesized that it may play a contributory role in disease development. In the acute-phase response SAA is synthesized by the liver and transported primarily in association with HDL. However, there is a growing literature suggesting that localized synthesis of SAA within the vasculature, or adipose tissue, may play a distinct role in disease development. Furthermore, SAA can be found in association with apoB-containing lipoproteins, in which its biological activity may be different. Summary: This review will discuss recent experimental evidence supporting a causal role of SAA with atherosclerosis.
Original language | English |
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Pages (from-to) | 302-307 |
Number of pages | 6 |
Journal | Current Opinion in Lipidology |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2011 |
Keywords
- HDL
- cardiovascular disease
- inflammation
- obesity
- proteoglycans
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Genetics
- Nutrition and Dietetics
- Cardiology and Cardiovascular Medicine
- Cell Biology