Serum Amyloid A is not obligatory for high-fat, high-sucrose, cholesterol-fed diet-induced obesity and its metabolic and inflammatory complications

Ailing Ji, Andrea C. Trumbauer, Victoria P. Noffsinger, Hayce Jeon, Avery C. Patrick, Frederick C. De Beer, Nancy R. Webb, Lisa R. Tannock, Preetha Shridas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Several studies in the past have reported positive correlations between circulating Serum amyloid A (SAA) levels and obesity. However, based on limited number of studies involving appropriate mouse models, the role of SAA in the development of obesity and obesityrelated metabolic consequences has not been established. Accordingly, herein, we have examined the role of SAA in the development of obesity and its associated metabolic complications in vivo using mice deficient for all three inducible forms of SAA: SAA1.1, SAA2.1 and SAA3 (TKO). Male and female mice were rendered obese by feeding a high fat, high sucrose diet with added cholesterol (HFHSC) and control mice were fed rodent chow diet. Here, we show that the deletion of SAA does not affect diet-induced obesity, hepatic lipid metabolism or adipose tissue inflammation. However, there was a modest effect on glucose metabolism. The results of this study confirm previous findings that SAA levels are elevated in adipose tissues as well as in the circulation in diet-induced obese mice. However, the three acute phase SAAs do not play a causative role in the development of obesity or obesity- associated adipose tissue inflammation and dyslipidemia.

Original languageEnglish
Article numbere0266688
JournalPLoS ONE
Volume17
Issue number4 April
DOIs
StatePublished - Apr 2022

Bibliographical note

Publisher Copyright:
© 2022 Ji et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ASJC Scopus subject areas

  • General

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