Serum amyloid A protein and C-reactive protein levels in pulmonary tuberculosis: Relationship to amyloidosis

F. C. de Beer, A. E. Nel, R. P. Gie, P. R. Donald, A. F. Strachan

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

C-reactive protein and serum amyloid A protein levels were measured in 54 patients with pulmonary tuberculosis. The primary tuberculous complex was associated with an insignificant acute phase response, while post-primary tuberculosis without evidence of lung destruction caused modest increases in C-reactive protein and serum amyloid A protein. In most patients with post-primary pulmonary tuberculosis with significant pulmonary destruction there was a major acute phase response, with very high serum amyloid A protein and C-reactive protein levels. The response in these patients is most likely to be due to secondary bacterial infection in addition to infection by Mycobacterium tuberculosis. Patients with miliary tuberculosis showed a major acute phase response. Serum amyloid A protein and C-reactive protein levels decreased rapidly after inititation of treatment in the patients with post-primary tuberculosis without significant pulmonary destruction.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalThorax
Volume39
Issue number3
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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