Serum C-reactive protein levels in the management of infection in acute leukaemia

Ian D. Starke; Frederick C. De Beer; J. Peter Donnelly; Daniel Catovsky; John M. Goldman; David A.G. Galton; Mark B. Pepys

doi:10.1016/0277-5379(84)90076-2

Serum C-reactive protein levels in the management of infection in acute leukaemia

Ian D. Starke, Frederick C. De Beer, J. Peter Donnelly, Daniel Catovsky, John M. Goldman, David A.G. Galton, Mark B. Pepys

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31 Scopus citations

Abstract

C-reactive protein (CRP) was measured serially in 29 patients with acute leukaemia. Sixty-four febrile episodes (≥38°C) occurred during 37 periods of neutropenia (<0.5 × 10⁹/l). In all of 41 microbiologically or clinically documented infections the maximum CRP level exceeded 30 mg/l, and in 25 it was greater than 100 mg/l. In no case in which the CRP level remained below 30 mg/l for 48 hr after the onset of fever was any clinical or microbiological evidence of infection obtained. The CRP level during documented infection began to fall 24-48 hr after appropriate treatment was begun. A CRP level above 30 mg/l in neutropenic patients was associated with early recurrence of fever if systemic antibiotics were discontinued. Graft-vs-host disease, without infection, did not result in high levels of CRP.

Original language	English
Pages (from-to)	319-325
Number of pages	7
Journal	European Journal of Cancer and Clinical Oncology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0277-5379(84)90076-2
State	Published - Mar 1984

Bibliographical note

Funding Information:
Accepted 25 August 1983. *Grant support: Medical Research Council Programme Grant G979/51 to MBP; Leukaemia Research Fund support for JPD. IPresent address: Department of Medicine, Guy’s Hospital, London Bridge, London SE1 9RT, U.K. llTo whom requests for reprints should be addressed.

ASJC Scopus subject areas

Oncology

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10.1016/0277-5379(84)90076-2

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title = "Serum C-reactive protein levels in the management of infection in acute leukaemia",

abstract = "C-reactive protein (CRP) was measured serially in 29 patients with acute leukaemia. Sixty-four febrile episodes (≥38°C) occurred during 37 periods of neutropenia (<0.5 × 109/l). In all of 41 microbiologically or clinically documented infections the maximum CRP level exceeded 30 mg/l, and in 25 it was greater than 100 mg/l. In no case in which the CRP level remained below 30 mg/l for 48 hr after the onset of fever was any clinical or microbiological evidence of infection obtained. The CRP level during documented infection began to fall 24-48 hr after appropriate treatment was begun. A CRP level above 30 mg/l in neutropenic patients was associated with early recurrence of fever if systemic antibiotics were discontinued. Graft-vs-host disease, without infection, did not result in high levels of CRP.",

author = "Starke, {Ian D.} and {De Beer}, {Frederick C.} and Donnelly, {J. Peter} and Daniel Catovsky and Goldman, {John M.} and Galton, {David A.G.} and Pepys, {Mark B.}",

note = "Funding Information: Accepted 25 August 1983. *Grant support: Medical Research Council Programme Grant G979/51 to MBP; Leukaemia Research Fund support for JPD. IPresent address: Department of Medicine, Guy{\textquoteright}s Hospital, London Bridge, London SE1 9RT, U.K. llTo whom requests for reprints should be addressed.",

year = "1984",

month = mar,

doi = "10.1016/0277-5379(84)90076-2",

language = "English",

volume = "20",

pages = "319--325",

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T1 - Serum C-reactive protein levels in the management of infection in acute leukaemia

AU - Starke, Ian D.

AU - De Beer, Frederick C.

AU - Donnelly, J. Peter

AU - Catovsky, Daniel

AU - Goldman, John M.

AU - Galton, David A.G.

AU - Pepys, Mark B.

N1 - Funding Information: Accepted 25 August 1983. *Grant support: Medical Research Council Programme Grant G979/51 to MBP; Leukaemia Research Fund support for JPD. IPresent address: Department of Medicine, Guy’s Hospital, London Bridge, London SE1 9RT, U.K. llTo whom requests for reprints should be addressed.

PY - 1984/3

Y1 - 1984/3

N2 - C-reactive protein (CRP) was measured serially in 29 patients with acute leukaemia. Sixty-four febrile episodes (≥38°C) occurred during 37 periods of neutropenia (<0.5 × 109/l). In all of 41 microbiologically or clinically documented infections the maximum CRP level exceeded 30 mg/l, and in 25 it was greater than 100 mg/l. In no case in which the CRP level remained below 30 mg/l for 48 hr after the onset of fever was any clinical or microbiological evidence of infection obtained. The CRP level during documented infection began to fall 24-48 hr after appropriate treatment was begun. A CRP level above 30 mg/l in neutropenic patients was associated with early recurrence of fever if systemic antibiotics were discontinued. Graft-vs-host disease, without infection, did not result in high levels of CRP.

AB - C-reactive protein (CRP) was measured serially in 29 patients with acute leukaemia. Sixty-four febrile episodes (≥38°C) occurred during 37 periods of neutropenia (<0.5 × 109/l). In all of 41 microbiologically or clinically documented infections the maximum CRP level exceeded 30 mg/l, and in 25 it was greater than 100 mg/l. In no case in which the CRP level remained below 30 mg/l for 48 hr after the onset of fever was any clinical or microbiological evidence of infection obtained. The CRP level during documented infection began to fall 24-48 hr after appropriate treatment was begun. A CRP level above 30 mg/l in neutropenic patients was associated with early recurrence of fever if systemic antibiotics were discontinued. Graft-vs-host disease, without infection, did not result in high levels of CRP.

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JO - European Journal of Cancer and Clinical Oncology

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ER -

Serum C-reactive protein levels in the management of infection in acute leukaemia

Abstract

Bibliographical note

ASJC Scopus subject areas

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