Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction

Madhav Swaminathan; Brian J. McCreath; Barbara G. Phillips-Bute; Mark F. Newman; Joseph P. Mathew; Peter K. Smith; James A. Blumenthal; Mark Stafford-Smith; Hilary P. Grocott; Steven E. Hill; J. G. Reves; Debra A. Schwinn; David Warner; Malissa Harris; Jerry L. Kirchner; Brenda Mickley; Mandy Barnes; Elizabeth Carver; Bonita L. Funk; E. D. Derilus; Jason Hawkins; Terri Moore; Chonna Campbell; Amanda Cheek; Tanya Kagarise; Tori Latiker; Erich Lauff; Melanie Tirronen; Regina DeLacy; William Hansley; Yvonne M. Connelly; William D. White; Michael A. Babyak; Daniel B. Mark; Michael H. Sketch; Carmelo Graffagnino; Daniel T. Laskowitz; John R. Lynch; Ann M. Saunders; Warren J. Strittmatter; Kathleen A. Welsh-Bohmer; Ellen Bennett; Greg Smigla; Ian Shearer; Robert W. Anderson; Thomas A. D'Amico; R. Duane Davis; Donald D. Glower; R. David Harpole; James Jaggers; Robert H. Jones; Kevin Landolfo; James E. Lowe; Robert H. Messier; Carmelo Milano; Eric M. Toloza; Walter G. Wolfe

doi:10.1097/00000539-200207000-00001

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction

Madhav Swaminathan, Brian J. McCreath, Barbara G. Phillips-Bute, Mark F. Newman, Joseph P. Mathew, Peter K. Smith, James A. Blumenthal, Mark Stafford-Smith, Hilary P. Grocott, Steven E. Hill, J. G. Reves, Debra A. Schwinn, David Warner, Malissa Harris, Jerry L. Kirchner, Brenda Mickley, Mandy Barnes, Elizabeth Carver, Bonita L. Funk, E. D. DerilusJason Hawkins, Terri Moore, Chonna Campbell, Amanda Cheek, Tanya Kagarise, Tori Latiker, Erich Lauff, Melanie Tirronen, Regina DeLacy, William Hansley, Yvonne M. Connelly, William D. White, Michael A. Babyak, Daniel B. Mark, Michael H. Sketch, Carmelo Graffagnino, Daniel T. Laskowitz, John R. Lynch, Ann M. Saunders, Warren J. Strittmatter, Kathleen A. Welsh-Bohmer, Ellen Bennett, Greg Smigla, Ian Shearer, Robert W. Anderson, Thomas A. D'Amico, R. Duane Davis, Donald D. Glower, R. David Harpole, James Jaggers, Robert H. Jones, Kevin Landolfo, James E. Lowe, Robert H. Messier, Carmelo Milano, Eric M. Toloza, Walter G. Wolfe

Anesthesiology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Anesthesia and Analgesia
Volume	95
Issue number	1
DOIs	https://doi.org/10.1097/00000539-200207000-00001
State	Published - 2002

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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Swaminathan, M., McCreath, B. J., Phillips-Bute, B. G., Newman, M. F., Mathew, J. P., Smith, P. K., Blumenthal, J. A., Stafford-Smith, M., Grocott, H. P., Hill, S. E., Reves, J. G., Schwinn, D. A., Warner, D., Harris, M., Kirchner, J. L., Mickley, B., Barnes, M., Carver, E., Funk, B. L., ... Wolfe, W. G. (2002). Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction. Anesthesia and Analgesia, 95(1), 1-8. https://doi.org/10.1097/00000539-200207000-00001

@article{bfc78667428a419f851f5b6b26781ca0,

title = "Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction",

abstract = "Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.",

author = "Madhav Swaminathan and McCreath, {Brian J.} and Phillips-Bute, {Barbara G.} and Newman, {Mark F.} and Mathew, {Joseph P.} and Smith, {Peter K.} and Blumenthal, {James A.} and Mark Stafford-Smith and Grocott, {Hilary P.} and Hill, {Steven E.} and Reves, {J. G.} and Schwinn, {Debra A.} and David Warner and Malissa Harris and Kirchner, {Jerry L.} and Brenda Mickley and Mandy Barnes and Elizabeth Carver and Funk, {Bonita L.} and Derilus, {E. D.} and Jason Hawkins and Terri Moore and Chonna Campbell and Amanda Cheek and Tanya Kagarise and Tori Latiker and Erich Lauff and Melanie Tirronen and Regina DeLacy and William Hansley and Connelly, {Yvonne M.} and White, {William D.} and Babyak, {Michael A.} and Mark, {Daniel B.} and Sketch, {Michael H.} and Carmelo Graffagnino and Laskowitz, {Daniel T.} and Lynch, {John R.} and Saunders, {Ann M.} and Strittmatter, {Warren J.} and Welsh-Bohmer, {Kathleen A.} and Ellen Bennett and Greg Smigla and Ian Shearer and Anderson, {Robert W.} and D'Amico, {Thomas A.} and {Duane Davis}, R. and Glower, {Donald D.} and Harpole, {R. David} and James Jaggers and Jones, {Robert H.} and Kevin Landolfo and Lowe, {James E.} and Messier, {Robert H.} and Carmelo Milano and Toloza, {Eric M.} and Wolfe, {Walter G.}",

year = "2002",

doi = "10.1097/00000539-200207000-00001",

language = "English",

volume = "95",

pages = "1--8",

number = "1",

}

Swaminathan, M, McCreath, BJ, Phillips-Bute, BG, Newman, MF, Mathew, JP, Smith, PK, Blumenthal, JA, Stafford-Smith, M, Grocott, HP, Hill, SE, Reves, JG, Schwinn, DA, Warner, D, Harris, M, Kirchner, JL, Mickley, B, Barnes, M, Carver, E, Funk, BL, Derilus, ED, Hawkins, J, Moore, T, Campbell, C, Cheek, A, Kagarise, T, Latiker, T, Lauff, E, Tirronen, M, DeLacy, R, Hansley, W, Connelly, YM, White, WD, Babyak, MA, Mark, DB, Sketch, MH, Graffagnino, C, Laskowitz, DT, Lynch, JR, Saunders, AM, Strittmatter, WJ, Welsh-Bohmer, KA, Bennett, E, Smigla, G, Shearer, I, Anderson, RW, D'Amico, TA, Duane Davis, R, Glower, DD, Harpole, RD, Jaggers, J, Jones, RH, Landolfo, K, Lowe, JE, Messier, RH, Milano, C, Toloza, EM & Wolfe, WG 2002, 'Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction', Anesthesia and Analgesia, vol. 95, no. 1, pp. 1-8. https://doi.org/10.1097/00000539-200207000-00001

TY - JOUR

T1 - Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction

AU - Swaminathan, Madhav

AU - McCreath, Brian J.

AU - Phillips-Bute, Barbara G.

AU - Newman, Mark F.

AU - Mathew, Joseph P.

AU - Smith, Peter K.

AU - Blumenthal, James A.

AU - Stafford-Smith, Mark

AU - Grocott, Hilary P.

AU - Hill, Steven E.

AU - Reves, J. G.

AU - Schwinn, Debra A.

AU - Warner, David

AU - Harris, Malissa

AU - Kirchner, Jerry L.

AU - Mickley, Brenda

AU - Barnes, Mandy

AU - Carver, Elizabeth

AU - Funk, Bonita L.

AU - Derilus, E. D.

AU - Hawkins, Jason

AU - Moore, Terri

AU - Campbell, Chonna

AU - Cheek, Amanda

AU - Kagarise, Tanya

AU - Latiker, Tori

AU - Lauff, Erich

AU - Tirronen, Melanie

AU - DeLacy, Regina

AU - Hansley, William

AU - Connelly, Yvonne M.

AU - White, William D.

AU - Babyak, Michael A.

AU - Mark, Daniel B.

AU - Sketch, Michael H.

AU - Graffagnino, Carmelo

AU - Laskowitz, Daniel T.

AU - Lynch, John R.

AU - Saunders, Ann M.

AU - Strittmatter, Warren J.

AU - Welsh-Bohmer, Kathleen A.

AU - Bennett, Ellen

AU - Smigla, Greg

AU - Shearer, Ian

AU - Anderson, Robert W.

AU - D'Amico, Thomas A.

AU - Duane Davis, R.

AU - Glower, Donald D.

AU - Harpole, R. David

AU - Jaggers, James

AU - Jones, Robert H.

AU - Landolfo, Kevin

AU - Lowe, James E.

AU - Messier, Robert H.

AU - Milano, Carmelo

AU - Toloza, Eric M.

AU - Wolfe, Walter G.

PY - 2002

Y1 - 2002

N2 - Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.

AB - Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=0036294908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036294908&partnerID=8YFLogxK

U2 - 10.1097/00000539-200207000-00001

DO - 10.1097/00000539-200207000-00001

M3 - Article

C2 - 12088934

AN - SCOPUS:0036294908

VL - 95

SP - 1

EP - 8

IS - 1

ER -

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction

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