Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction

Madhav Swaminathan, Brian J. McCreath, Barbara G. Phillips-Bute, Mark F. Newman, Joseph P. Mathew, Peter K. Smith, James A. Blumenthal, Mark Stafford-Smith, Hilary P. Grocott, Steven E. Hill, J. G. Reves, Debra A. Schwinn, David Warner, Malissa Harris, Jerry L. Kirchner, Brenda Mickley, Mandy Barnes, Elizabeth Carver, Bonita L. Funk, E. D. DerilusJason Hawkins, Terri Moore, Chonna Campbell, Amanda Cheek, Tanya Kagarise, Tori Latiker, Erich Lauff, Melanie Tirronen, Regina DeLacy, William Hansley, Yvonne M. Connelly, William D. White, Michael A. Babyak, Daniel B. Mark, Michael H. Sketch, Carmelo Graffagnino, Daniel T. Laskowitz, John R. Lynch, Ann M. Saunders, Warren J. Strittmatter, Kathleen A. Welsh-Bohmer, Ellen Bennett, Greg Smigla, Ian Shearer, Robert W. Anderson, Thomas A. D'Amico, R. Duane Davis, Donald D. Glower, R. David Harpole, James Jaggers, Robert H. Jones, Kevin Landolfo, James E. Lowe, Robert H. Messier, Carmelo Milano, Eric M. Toloza, Walter G. Wolfe

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalAnesthesia and Analgesia
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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