Serum zinc levels and Alzheimer's disease

L. L. Rulon, J. D. Robertson, M. A. Lovell, M. A. Deibel, W. D. Ehmann, W. R. Markesbery

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum was observed in AD subjects (136.4 ± 66.8 μg/dL) compared with age-matched control subjects (71.1 ± 35.0 μg/dL). No significant differences were observed between AD and control zinc concentrations in the amygdala, hippocampus, cerebellum, and superior and middle temporal gryi.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalBiological Trace Element Research
Volume75
Issue number1-3
DOIs
StatePublished - 2000

Keywords

  • Alzheimer's disease
  • Brain
  • FAAS
  • INAA
  • Serum
  • Zinc

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Inorganic Chemistry
  • Biochemistry, medical

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