Serum zinc levels and Alzheimer's disease

L. L. Rulon; J. D. Robertson; M. A. Lovell; M. A. Deibel; W. D. Ehmann; W. R. Markesbery

doi:10.1385/BTER:75:1-3:79

Serum zinc levels and Alzheimer's disease

L. L. Rulon, J. D. Robertson, M. A. Lovell, M. A. Deibel, W. D. Ehmann, W. R. Markesbery

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum was observed in AD subjects (136.4 ± 66.8 μg/dL) compared with age-matched control subjects (71.1 ± 35.0 μg/dL). No significant differences were observed between AD and control zinc concentrations in the amygdala, hippocampus, cerebellum, and superior and middle temporal gryi.

Original language	English
Pages (from-to)	79-85
Number of pages	7
Journal	Biological Trace Element Research
Volume	75
Issue number	1-3
DOIs	https://doi.org/10.1385/BTER:75:1-3:79
State	Published - 2000

Keywords

Alzheimer's disease
Brain
FAAS
INAA
Serum
Zinc

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry
Inorganic Chemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1385/BTER:75:1-3:79

Cite this

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AU - Rulon, L. L.

AU - Robertson, J. D.

AU - Lovell, M. A.

AU - Deibel, M. A.

AU - Ehmann, W. D.

AU - Markesbery, W. R.

PY - 2000

Y1 - 2000

N2 - Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum was observed in AD subjects (136.4 ± 66.8 μg/dL) compared with age-matched control subjects (71.1 ± 35.0 μg/dL). No significant differences were observed between AD and control zinc concentrations in the amygdala, hippocampus, cerebellum, and superior and middle temporal gryi.

AB - Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum was observed in AD subjects (136.4 ± 66.8 μg/dL) compared with age-matched control subjects (71.1 ± 35.0 μg/dL). No significant differences were observed between AD and control zinc concentrations in the amygdala, hippocampus, cerebellum, and superior and middle temporal gryi.

KW - Alzheimer's disease

KW - Brain

KW - FAAS

KW - INAA

KW - Serum

KW - Zinc

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EP - 85

JO - Biological Trace Element Research

JF - Biological Trace Element Research

IS - 1-3

ER -

Serum zinc levels and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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