TY - JOUR
T1 - Session III
T2 - Mechanisms of age-related cognitive change and targets for intervention: Inflammatory, oxidative, and metabolic processes
AU - Craft, Suzanne
AU - Foster, Thomas C.
AU - Landfield, Philip W.
AU - Maier, Steven F.
AU - Resnick, Susan M.
AU - Yaffe, Kristine
PY - 2012/6/15
Y1 - 2012/6/15
N2 - There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.
AB - There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.
KW - Aging
KW - Cognition
KW - Inflammation
KW - Metabolism
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84863669043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863669043&partnerID=8YFLogxK
U2 - 10.1093/gerona/gls112
DO - 10.1093/gerona/gls112
M3 - Review article
C2 - 22570133
AN - SCOPUS:84863669043
SN - 1079-5006
VL - 67 A
SP - 754
EP - 759
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 7
ER -