Session III: Mechanisms of age-related cognitive change and targets for intervention: Inflammatory, oxidative, and metabolic processes

Suzanne Craft, Thomas C. Foster, Philip W. Landfield, Steven F. Maier, Susan M. Resnick, Kristine Yaffe

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.

Original languageEnglish
Pages (from-to)754-759
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67 A
Issue number7
DOIs
StatePublished - Jun 15 2012

Keywords

  • Aging
  • Cognition
  • Inflammation
  • Metabolism
  • Oxidative stress

ASJC Scopus subject areas

  • General Medicine

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