Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel

Lauren C. Harshman; Yu Hui Chen; Glenn Liu; Michael A. Carducci; David Jarrard; Robert Dreicer; Noah Hahn; Jorge A. Garcia; Maha Hussain; Daniel Shevrin; Mario Eisenberger; Manish Kohli; Elizabeth R. Plimack; Matthew Cooney; Nicholas J. Vogelzang; Joel Picus; Robert Dipaola; Christopher J. Sweeney

doi:10.1200/JCO.2017.75.3921

Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel

Lauren C. Harshman, Yu Hui Chen, Glenn Liu, Michael A. Carducci, David Jarrard, Robert Dreicer, Noah Hahn, Jorge A. Garcia, Maha Hussain, Daniel Shevrin, Mario Eisenberger, Manish Kohli, Elizabeth R. Plimack, Matthew Cooney, Nicholas J. Vogelzang, Joel Picus, Robert Dipaola, Christopher J. Sweeney

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Abstract

Purpose: We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinical trial comparing androgen-deprivation therapy (ADT) plus docetaxel with ADT alone for initial metastatic hormone-sensitive prostate cancer. Methods: We performed a landmark survival analysis at 7 months using the E3805 Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) database (ClinicalTrials.gov identifier: NCT00309985). Inclusion required at least 7 months of follow-up and PSA levels at 7 months from ADT initiation. We used the prognostic classifiers identified in a previously reported trial (Southwest Oncology Group 9346) of PSA ≤ 0.2, > 0.2 to 4, and > 4 ng/mL. Results: Seven hundred nineteen of 790 patients were eligible for this subanalysis; 358 were treated with ADT plus docetaxel, and 361 were treated with ADT alone. Median follow-up time was 23.1 months. On multivariable analysis, achieving a 7-month PSA ≤ 0.2 ng/mL was more likely with docetaxel, low-volume disease, prior local therapy, and lower baseline PSAs (all P < .01). Across all patients, median overall survival was significantly longer if 7-month PSA reached ≤ 0.2 ng/mL compared with > 4 ng/mL (median survival, 60.4 v 22.2 months, respectively; P < .001). On multivariable analysis, 7-month PSA ≤ 0.2 and low volume disease were prognostic of longer overall survival (all P < 0.01). The addition of docetaxel increased the likelihood of achieving a PSA ≤ 0.2 ng/mL at 7 months (45.3% v 28.8% of patients on ADT alone). Patients on ADT alone who achieved a 7-month PSA ≤ 0.2 ng/mL had the best survival and were more likely to have low-volume disease (56.7%). Conclusion: PSA ≤ 0.2 ng/mL at 7 months is prognostic for longer overall survival with ADT for metastatic hormone-sensitive prostate cancer irrespective of docetaxel administration. Adding docetaxel increased the likelihood of a lower PSA and improved survival.

Original language	English
Pages (from-to)	376-382
Number of pages	7
Journal	Journal of Clinical Oncology
Volume	36
Issue number	4
DOIs	https://doi.org/10.1200/JCO.2017.75.3921
State	Published - Feb 1 2018

Bibliographical note

Funding Information:
Sanofi provided docetaxel for early use, and financial grant support was provided by the National Cancer Institute Cancer Therapy Evaluation Program and the Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN). This study was coordinated by the ECOG-ACRIN Cancer Research Group (Peter J. O'Dwyer, MD, and Mitchell D. Schnall, MD, PhD, group co-chairs) and supported by the National Cancer Institute of the National Institutes of Health under the following grant numbers: CA180820, CA180794, CA180795, CA180790, CA180802, CA180821, CA180833, CA180847, CA180853, CA180867, CA180888, CA180801, and CA189829.

Publisher Copyright:
© 2017 by American Society of Clinical Oncology.

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1200/JCO.2017.75.3921

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Harshman, L. C., Chen, Y. H., Liu, G., Carducci, M. A., Jarrard, D., Dreicer, R., Hahn, N., Garcia, J. A., Hussain, M., Shevrin, D., Eisenberger, M., Kohli, M., Plimack, E. R., Cooney, M., Vogelzang, N. J., Picus, J., Dipaola, R., & Sweeney, C. J. (2018). Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel. Journal of Clinical Oncology, 36(4), 376-382. https://doi.org/10.1200/JCO.2017.75.3921

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title = "Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel",

abstract = "Purpose: We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinical trial comparing androgen-deprivation therapy (ADT) plus docetaxel with ADT alone for initial metastatic hormone-sensitive prostate cancer. Methods: We performed a landmark survival analysis at 7 months using the E3805 Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) database (ClinicalTrials.gov identifier: NCT00309985). Inclusion required at least 7 months of follow-up and PSA levels at 7 months from ADT initiation. We used the prognostic classifiers identified in a previously reported trial (Southwest Oncology Group 9346) of PSA ≤ 0.2, > 0.2 to 4, and > 4 ng/mL. Results: Seven hundred nineteen of 790 patients were eligible for this subanalysis; 358 were treated with ADT plus docetaxel, and 361 were treated with ADT alone. Median follow-up time was 23.1 months. On multivariable analysis, achieving a 7-month PSA ≤ 0.2 ng/mL was more likely with docetaxel, low-volume disease, prior local therapy, and lower baseline PSAs (all P < .01). Across all patients, median overall survival was significantly longer if 7-month PSA reached ≤ 0.2 ng/mL compared with > 4 ng/mL (median survival, 60.4 v 22.2 months, respectively; P < .001). On multivariable analysis, 7-month PSA ≤ 0.2 and low volume disease were prognostic of longer overall survival (all P < 0.01). The addition of docetaxel increased the likelihood of achieving a PSA ≤ 0.2 ng/mL at 7 months (45.3% v 28.8% of patients on ADT alone). Patients on ADT alone who achieved a 7-month PSA ≤ 0.2 ng/mL had the best survival and were more likely to have low-volume disease (56.7%). Conclusion: PSA ≤ 0.2 ng/mL at 7 months is prognostic for longer overall survival with ADT for metastatic hormone-sensitive prostate cancer irrespective of docetaxel administration. Adding docetaxel increased the likelihood of a lower PSA and improved survival.",

author = "Harshman, {Lauren C.} and Chen, {Yu Hui} and Glenn Liu and Carducci, {Michael A.} and David Jarrard and Robert Dreicer and Noah Hahn and Garcia, {Jorge A.} and Maha Hussain and Daniel Shevrin and Mario Eisenberger and Manish Kohli and Plimack, {Elizabeth R.} and Matthew Cooney and Vogelzang, {Nicholas J.} and Joel Picus and Robert Dipaola and Sweeney, {Christopher J.}",

note = "Funding Information: Sanofi provided docetaxel for early use, and financial grant support was provided by the National Cancer Institute Cancer Therapy Evaluation Program and the Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN). This study was coordinated by the ECOG-ACRIN Cancer Research Group (Peter J. O'Dwyer, MD, and Mitchell D. Schnall, MD, PhD, group co-chairs) and supported by the National Cancer Institute of the National Institutes of Health under the following grant numbers: CA180820, CA180794, CA180795, CA180790, CA180802, CA180821, CA180833, CA180847, CA180853, CA180867, CA180888, CA180801, and CA189829. Publisher Copyright: {\textcopyright} 2017 by American Society of Clinical Oncology.",

year = "2018",

month = feb,

day = "1",

doi = "10.1200/JCO.2017.75.3921",

language = "English",

volume = "36",

pages = "376--382",

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Harshman, LC, Chen, YH, Liu, G, Carducci, MA, Jarrard, D, Dreicer, R, Hahn, N, Garcia, JA, Hussain, M, Shevrin, D, Eisenberger, M, Kohli, M, Plimack, ER, Cooney, M, Vogelzang, NJ, Picus, J, Dipaola, R & Sweeney, CJ 2018, 'Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel', Journal of Clinical Oncology, vol. 36, no. 4, pp. 376-382. https://doi.org/10.1200/JCO.2017.75.3921

TY - JOUR

T1 - Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel

AU - Harshman, Lauren C.

AU - Chen, Yu Hui

AU - Liu, Glenn

AU - Carducci, Michael A.

AU - Jarrard, David

AU - Dreicer, Robert

AU - Hahn, Noah

AU - Garcia, Jorge A.

AU - Hussain, Maha

AU - Shevrin, Daniel

AU - Eisenberger, Mario

AU - Kohli, Manish

AU - Plimack, Elizabeth R.

AU - Cooney, Matthew

AU - Vogelzang, Nicholas J.

AU - Picus, Joel

AU - Dipaola, Robert

AU - Sweeney, Christopher J.

N1 - Funding Information: Sanofi provided docetaxel for early use, and financial grant support was provided by the National Cancer Institute Cancer Therapy Evaluation Program and the Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN). This study was coordinated by the ECOG-ACRIN Cancer Research Group (Peter J. O'Dwyer, MD, and Mitchell D. Schnall, MD, PhD, group co-chairs) and supported by the National Cancer Institute of the National Institutes of Health under the following grant numbers: CA180820, CA180794, CA180795, CA180790, CA180802, CA180821, CA180833, CA180847, CA180853, CA180867, CA180888, CA180801, and CA189829. Publisher Copyright: © 2017 by American Society of Clinical Oncology.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Purpose: We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinical trial comparing androgen-deprivation therapy (ADT) plus docetaxel with ADT alone for initial metastatic hormone-sensitive prostate cancer. Methods: We performed a landmark survival analysis at 7 months using the E3805 Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) database (ClinicalTrials.gov identifier: NCT00309985). Inclusion required at least 7 months of follow-up and PSA levels at 7 months from ADT initiation. We used the prognostic classifiers identified in a previously reported trial (Southwest Oncology Group 9346) of PSA ≤ 0.2, > 0.2 to 4, and > 4 ng/mL. Results: Seven hundred nineteen of 790 patients were eligible for this subanalysis; 358 were treated with ADT plus docetaxel, and 361 were treated with ADT alone. Median follow-up time was 23.1 months. On multivariable analysis, achieving a 7-month PSA ≤ 0.2 ng/mL was more likely with docetaxel, low-volume disease, prior local therapy, and lower baseline PSAs (all P < .01). Across all patients, median overall survival was significantly longer if 7-month PSA reached ≤ 0.2 ng/mL compared with > 4 ng/mL (median survival, 60.4 v 22.2 months, respectively; P < .001). On multivariable analysis, 7-month PSA ≤ 0.2 and low volume disease were prognostic of longer overall survival (all P < 0.01). The addition of docetaxel increased the likelihood of achieving a PSA ≤ 0.2 ng/mL at 7 months (45.3% v 28.8% of patients on ADT alone). Patients on ADT alone who achieved a 7-month PSA ≤ 0.2 ng/mL had the best survival and were more likely to have low-volume disease (56.7%). Conclusion: PSA ≤ 0.2 ng/mL at 7 months is prognostic for longer overall survival with ADT for metastatic hormone-sensitive prostate cancer irrespective of docetaxel administration. Adding docetaxel increased the likelihood of a lower PSA and improved survival.

AB - Purpose: We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinical trial comparing androgen-deprivation therapy (ADT) plus docetaxel with ADT alone for initial metastatic hormone-sensitive prostate cancer. Methods: We performed a landmark survival analysis at 7 months using the E3805 Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) database (ClinicalTrials.gov identifier: NCT00309985). Inclusion required at least 7 months of follow-up and PSA levels at 7 months from ADT initiation. We used the prognostic classifiers identified in a previously reported trial (Southwest Oncology Group 9346) of PSA ≤ 0.2, > 0.2 to 4, and > 4 ng/mL. Results: Seven hundred nineteen of 790 patients were eligible for this subanalysis; 358 were treated with ADT plus docetaxel, and 361 were treated with ADT alone. Median follow-up time was 23.1 months. On multivariable analysis, achieving a 7-month PSA ≤ 0.2 ng/mL was more likely with docetaxel, low-volume disease, prior local therapy, and lower baseline PSAs (all P < .01). Across all patients, median overall survival was significantly longer if 7-month PSA reached ≤ 0.2 ng/mL compared with > 4 ng/mL (median survival, 60.4 v 22.2 months, respectively; P < .001). On multivariable analysis, 7-month PSA ≤ 0.2 and low volume disease were prognostic of longer overall survival (all P < 0.01). The addition of docetaxel increased the likelihood of achieving a PSA ≤ 0.2 ng/mL at 7 months (45.3% v 28.8% of patients on ADT alone). Patients on ADT alone who achieved a 7-month PSA ≤ 0.2 ng/mL had the best survival and were more likely to have low-volume disease (56.7%). Conclusion: PSA ≤ 0.2 ng/mL at 7 months is prognostic for longer overall survival with ADT for metastatic hormone-sensitive prostate cancer irrespective of docetaxel administration. Adding docetaxel increased the likelihood of a lower PSA and improved survival.

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Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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