Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research

Philip A. Verhoef, Sujatha Kannan, Jamie L. Sturgill, Elizabeth W. Tucker, Peter E. Morris, Andrew C. Miller, Travis R. Sexton, Jay L. Koyner, Rana Hejal, Scott C. Brakenridge, Lyle L. Moldawer, Richard S. Hotchkiss, Teresa M. Blood, Monty B. Mazer, Scott Bolesta, Sheila A. Alexander, Donna Lee Armaignac, Steven L. Shein, Christopher Jones, Caroline D. HoemannAllan Doctor, Stuart H. Friess, Robert I. Parker, Alexandre T. Rotta, Kenneth E. Remy

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Objectives: Since the beginning of the coronavirus disease 2019 pandemic, hundreds of thousands of patients have been treated in ICUs across the globe. The severe acute respiratory syndrome-associated coronavirus 2 virus enters cells via the angiotensin-converting enzyme 2 receptor and activates several distinct inflammatory pathways, resulting in hematologic abnormalities and dysfunction in respiratory, cardiac, gastrointestinal renal, endocrine, dermatologic, and neurologic systems. This review summarizes the current state of research in coronavirus disease 2019 pathophysiology within the context of potential organ-based disease mechanisms and opportunities for translational research. Data Sources: Investigators from the Research Section of the Society of Critical Care Medicine were selected based on expertise in specific organ systems and research focus. Data were obtained from searches conducted in Medline via the PubMed portal, Directory of Open Access Journals, Excerpta Medica database, Latin American and Caribbean Health Sciences Literature, and Web of Science from an initial search from December 2019 to October 15, 2020, with a revised search to February 3, 2021. The medRxiv, Research Square, and clinical trial registries preprint servers also were searched to limit publication bias. Study Selection: Content experts selected studies that included mechanism-based relevance to the severe acute respiratory syndrome-associated coronavirus 2 virus or coronavirus disease 2019 disease. Data Extraction: Not applicable. Data Synthesis: Not applicable. Conclusions: Efforts to improve the care of critically ill coronavirus disease 2019 patients should be centered on understanding how severe acute respiratory syndrome-associated coronavirus 2 infection affects organ function. This review articulates specific targets for further research.

Original languageEnglish
Pages (from-to)E0374
JournalCritical Care Explorations
Volume3
Issue number3
DOIs
StatePublished - Mar 12 2021

Bibliographical note

Publisher Copyright:
© 2021 Critical Care Explorations. All rights reserved.

Keywords

  • angiotensin-converting enzyme 2 receptor
  • coronavirus disease 2019
  • critical illness
  • pandemic
  • severe acute respiratory syndrome-associated coronavirus 2

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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