Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias

Jenny Lutshumba; Donna M. Wilcock; Nancy L. Monson; Ann M. Stowe

doi:10.1016/j.nbd.2023.106202

Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias

Jenny Lutshumba, Donna M. Wilcock, Nancy L. Monson, Ann M. Stowe

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Neurological conditions such as Alzheimer's disease (AD) and related dementias (ADRD) present with many challenges due to the heterogeneity of the related disease(s), making it difficult to develop effective treatments. Additionally, the progression of ADRD-related pathologies presents differently between men and women. With two-thirds of the population affected with ADRD being women, ADRD has presented itself with a bias toward the female population. However, studies of ADRD generally do not incorporate sex-based differences in investigating the development and progression of the disease, which is detrimental to understanding and treating dementia. Additionally, recent implications for the adaptive immune system in the development of ADRD bring in new factors to be considered as part of the disease, including sex-based differences in immune response(s) during ADRD development. Here, we review the sex-based differences of pathological hallmarks of ADRD presentation and progression, sex-based differences in the adaptive immune system and how it changes with ADRD, and the importance of precision medicine in the development of a more targeted and personalized treatment for this devastating and prevalent neurodegenerative condition.

Original language	English
Article number	106202
Journal	Neurobiology of Disease
Volume	184
DOIs	https://doi.org/10.1016/j.nbd.2023.106202
State	Published - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023

Funding

We would like to thank Matthew Hazzard and Thomas Dolan, University of Kentucky, for creating the medical illustrations. This work has been supported by the University of Kentucky Lyman T. Johnson postdoctoral fellowship to JL, National Institute of Aging R56 AG074613 to AS, the University of Kentucky Alzheimer's Disease research center, National Institute of Neurological Disorders and Stroke awards R21 NS104509 and R01 NS102417 to NM supported this work. This project was also supported by the Texas Alzheimer's Research and Care Consortium (TARCC).

Funders	Funder number
University of Kentucky Alzheimer's Disease research center
National Institute on Aging	R56 AG074613
National Institute on Aging
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council	R21 NS104509, R01 NS102417
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council
University of Kentucky
Texas Alzheimer's Research and Care Consortium

Keywords

B lymphcoytes
Dementia
Estrogen
T lymphocytes
Tesosterone

ASJC Scopus subject areas

Neurology

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10.1016/j.nbd.2023.106202

Cite this

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abstract = "Neurological conditions such as Alzheimer's disease (AD) and related dementias (ADRD) present with many challenges due to the heterogeneity of the related disease(s), making it difficult to develop effective treatments. Additionally, the progression of ADRD-related pathologies presents differently between men and women. With two-thirds of the population affected with ADRD being women, ADRD has presented itself with a bias toward the female population. However, studies of ADRD generally do not incorporate sex-based differences in investigating the development and progression of the disease, which is detrimental to understanding and treating dementia. Additionally, recent implications for the adaptive immune system in the development of ADRD bring in new factors to be considered as part of the disease, including sex-based differences in immune response(s) during ADRD development. Here, we review the sex-based differences of pathological hallmarks of ADRD presentation and progression, sex-based differences in the adaptive immune system and how it changes with ADRD, and the importance of precision medicine in the development of a more targeted and personalized treatment for this devastating and prevalent neurodegenerative condition.",

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Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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