Sex Differences in Mitochondrial Function Following a Controlled Cortical Impact Traumatic Brain Injury in Rodents

Olivia J. Kalimon; Patrick G. Sullivan

doi:10.3389/fnmol.2021.753946

Sex Differences in Mitochondrial Function Following a Controlled Cortical Impact Traumatic Brain Injury in Rodents

Olivia J. Kalimon, Patrick G. Sullivan

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Traumatic brain injury (TBI) is a complex disease to study due to the multifactorial injury cascades occurring after the initial blow to the head. One of the most vital players in this secondary injury cascade, and therapeutic target of interest, is the mitochondrion. Mitochondria are important for the generation of cellular energy, regulation of cell death, and modulation of intracellular calcium which leaves these “powerhouses” especially susceptible to damage and dysfunction following traumatic brain injury. Most of the existing studies involving mitochondrial dysfunction after TBI have been performed in male rodent models, leaving a gap in knowledge on these same outcomes in females. This mini-review intends to highlight the available data on mitochondrial dysfunction in male and female rodents after controlled cortical impact (CCI) as a common model of TBI.

Original language	English
Article number	753946
Journal	Frontiers in Molecular Neuroscience
Volume	14
DOIs	https://doi.org/10.3389/fnmol.2021.753946
State	Published - Oct 13 2021

Bibliographical note

Funding Information:
PS’s effort was funded in part by NIH R01 NS112693-01A1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. OK’s effort was funded in part by a pre-doctoral fellowship from Kentucky Spinal Cord and Head Injury Research Trust (KSCHIRT).

Publisher Copyright:
© Copyright © 2021 Kalimon and Sullivan.

Keywords

CNS injury
bioenergetics
glucose utilization
oxidative stress
sex hormone influence

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Access to Document

10.3389/fnmol.2021.753946

Cite this

@article{c195ac6efafb4c0abdfb33f81833f34c,

title = "Sex Differences in Mitochondrial Function Following a Controlled Cortical Impact Traumatic Brain Injury in Rodents",

abstract = "Traumatic brain injury (TBI) is a complex disease to study due to the multifactorial injury cascades occurring after the initial blow to the head. One of the most vital players in this secondary injury cascade, and therapeutic target of interest, is the mitochondrion. Mitochondria are important for the generation of cellular energy, regulation of cell death, and modulation of intracellular calcium which leaves these “powerhouses” especially susceptible to damage and dysfunction following traumatic brain injury. Most of the existing studies involving mitochondrial dysfunction after TBI have been performed in male rodent models, leaving a gap in knowledge on these same outcomes in females. This mini-review intends to highlight the available data on mitochondrial dysfunction in male and female rodents after controlled cortical impact (CCI) as a common model of TBI.",

keywords = "CNS injury, bioenergetics, glucose utilization, oxidative stress, sex hormone influence",

author = "Kalimon, {Olivia J.} and Sullivan, {Patrick G.}",

note = "Funding Information: PS{\textquoteright}s effort was funded in part by NIH R01 NS112693-01A1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. OK{\textquoteright}s effort was funded in part by a pre-doctoral fellowship from Kentucky Spinal Cord and Head Injury Research Trust (KSCHIRT). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Kalimon and Sullivan.",

year = "2021",

month = oct,

day = "13",

doi = "10.3389/fnmol.2021.753946",

language = "English",

volume = "14",

}

TY - JOUR

T1 - Sex Differences in Mitochondrial Function Following a Controlled Cortical Impact Traumatic Brain Injury in Rodents

AU - Kalimon, Olivia J.

AU - Sullivan, Patrick G.

N1 - Funding Information: PS’s effort was funded in part by NIH R01 NS112693-01A1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. OK’s effort was funded in part by a pre-doctoral fellowship from Kentucky Spinal Cord and Head Injury Research Trust (KSCHIRT). Publisher Copyright: © Copyright © 2021 Kalimon and Sullivan.

PY - 2021/10/13

Y1 - 2021/10/13

N2 - Traumatic brain injury (TBI) is a complex disease to study due to the multifactorial injury cascades occurring after the initial blow to the head. One of the most vital players in this secondary injury cascade, and therapeutic target of interest, is the mitochondrion. Mitochondria are important for the generation of cellular energy, regulation of cell death, and modulation of intracellular calcium which leaves these “powerhouses” especially susceptible to damage and dysfunction following traumatic brain injury. Most of the existing studies involving mitochondrial dysfunction after TBI have been performed in male rodent models, leaving a gap in knowledge on these same outcomes in females. This mini-review intends to highlight the available data on mitochondrial dysfunction in male and female rodents after controlled cortical impact (CCI) as a common model of TBI.

AB - Traumatic brain injury (TBI) is a complex disease to study due to the multifactorial injury cascades occurring after the initial blow to the head. One of the most vital players in this secondary injury cascade, and therapeutic target of interest, is the mitochondrion. Mitochondria are important for the generation of cellular energy, regulation of cell death, and modulation of intracellular calcium which leaves these “powerhouses” especially susceptible to damage and dysfunction following traumatic brain injury. Most of the existing studies involving mitochondrial dysfunction after TBI have been performed in male rodent models, leaving a gap in knowledge on these same outcomes in females. This mini-review intends to highlight the available data on mitochondrial dysfunction in male and female rodents after controlled cortical impact (CCI) as a common model of TBI.

KW - CNS injury

KW - bioenergetics

KW - glucose utilization

KW - oxidative stress

KW - sex hormone influence

UR - http://www.scopus.com/inward/record.url?scp=85118113367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85118113367&partnerID=8YFLogxK

U2 - 10.3389/fnmol.2021.753946

DO - 10.3389/fnmol.2021.753946

M3 - Review article

AN - SCOPUS:85118113367

SN - 1662-5099

VL - 14

JO - Frontiers in Molecular Neuroscience

JF - Frontiers in Molecular Neuroscience

M1 - 753946

ER -

Sex Differences in Mitochondrial Function Following a Controlled Cortical Impact Traumatic Brain Injury in Rodents

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this