Abstract
Hematopoiesis is a continuous and well-regulated process requiring both the capacity for self-renewal and the potential for differentiation of hematopoietic stem cells. Multiple studies indicate that sex hormones exert significant effects on not only hematopoietic stem and progenitor cells, but also the development of hematopoietic lineages, resulting in sexual dimorphisms in normal hematopoiesis. Hematologic malignancies comprise a wide variety of cancers affecting the blood, bone marrow, and lymphatic system, such as leukemia, lymphoma, myeloma, myelodysplastic syndrome, and myeloproliferative diseases. Overall, males are at greater risk and have worse prognosis for most of these malignancies compared with females. A better understanding of the differences between male and female could be of substantial value in research as well as clinical management.
Original language | English |
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Pages (from-to) | 185-191 |
Number of pages | 7 |
Journal | Blood Science |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1 2022 |
Bibliographical note
Publisher Copyright:© 2022 De Gruyter Open Ltd. All rights reserved.
Keywords
- Hematopoietic stem cells
- Malignant hematopoiesis
- Normal hematopoiesis
- Sex hormones
- Sexual dimorphism
ASJC Scopus subject areas
- Hematology