Sex differences in normal and malignant hematopoiesis

Xiaojing Cui, Xinghui Zhao, Ying Liang

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Hematopoiesis is a continuous and well-regulated process requiring both the capacity for self-renewal and the potential for differentiation of hematopoietic stem cells. Multiple studies indicate that sex hormones exert significant effects on not only hematopoietic stem and progenitor cells, but also the development of hematopoietic lineages, resulting in sexual dimorphisms in normal hematopoiesis. Hematologic malignancies comprise a wide variety of cancers affecting the blood, bone marrow, and lymphatic system, such as leukemia, lymphoma, myeloma, myelodysplastic syndrome, and myeloproliferative diseases. Overall, males are at greater risk and have worse prognosis for most of these malignancies compared with females. A better understanding of the differences between male and female could be of substantial value in research as well as clinical management.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalBlood Science
Volume4
Issue number4
DOIs
StatePublished - Oct 1 2022

Bibliographical note

Publisher Copyright:
© 2022 De Gruyter Open Ltd. All rights reserved.

Keywords

  • Hematopoietic stem cells
  • Malignant hematopoiesis
  • Normal hematopoiesis
  • Sex hormones
  • Sexual dimorphism

ASJC Scopus subject areas

  • Hematology

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