Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon

Stephen B. Milam; Thomas B. Aufdemorte; Peter J. Sheridan; Robert G. Triplett; Joseph E. Van Sickels; G. Richard Holt

doi:10.1016/0030-4220(87)90025-9

Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon

Stephen B. Milam, Thomas B. Aufdemorte, Peter J. Sheridan, Robert G. Triplett, Joseph E. Van Sickels, G. Richard Holt

Oral Health Science

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.

Original language	English
Pages (from-to)	527-532
Number of pages	6
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	64
Issue number	5
DOIs	https://doi.org/10.1016/0030-4220(87)90025-9
State	Published - Nov 1987

Bibliographical note

Funding Information:
This research was supported by National Institutes of Health Program Project Grant 1 PO1 NS 1963-01. *Department of Cellular and Structural Biology, University of Texas Health Science Center. *‘Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ***Department of Cellular and Structural Biology and Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ****Department of Surgery, Division of Otorhinology, University of Texas Health Science Center. *****Department of Oral and Maxillofacial Surgery, Department of Pathology, Department of Surgery, Division of Otorhino-logy, University of Texas Health Science Center.

ASJC Scopus subject areas

Pathology and Forensic Medicine
General Dentistry

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10.1016/0030-4220(87)90025-9

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@article{8dad16d0fc3a401b98458ff952acbaad,

title = "Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon",

abstract = "The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.",

author = "Milam, {Stephen B.} and Aufdemorte, {Thomas B.} and Sheridan, {Peter J.} and Triplett, {Robert G.} and {Van Sickels}, {Joseph E.} and Holt, {G. Richard}",

note = "Funding Information: This research was supported by National Institutes of Health Program Project Grant 1 PO1 NS 1963-01. *Department of Cellular and Structural Biology, University of Texas Health Science Center. *{\textquoteleft}Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ***Department of Cellular and Structural Biology and Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ****Department of Surgery, Division of Otorhinology, University of Texas Health Science Center. *****Department of Oral and Maxillofacial Surgery, Department of Pathology, Department of Surgery, Division of Otorhino-logy, University of Texas Health Science Center.",

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AU - Sheridan, Peter J.

AU - Triplett, Robert G.

AU - Van Sickels, Joseph E.

AU - Holt, G. Richard

N1 - Funding Information: This research was supported by National Institutes of Health Program Project Grant 1 PO1 NS 1963-01. *Department of Cellular and Structural Biology, University of Texas Health Science Center. *‘Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ***Department of Cellular and Structural Biology and Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center. ****Department of Surgery, Division of Otorhinology, University of Texas Health Science Center. *****Department of Oral and Maxillofacial Surgery, Department of Pathology, Department of Surgery, Division of Otorhino-logy, University of Texas Health Science Center.

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N2 - The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.

AB - The localization of radiolabeled estradiol was examined in the temporomandibular complex of male baboons by means of an autoradiographic technique. Five baboons were studied. Four animals received only the tritiated estrogen (1 μg/kgm) and one animal, which served as the control, received both the tritiated estrogen and the unlabeled estrogen (100 μg/kgm). The study failed to demonstrate nuclear uptake and retention of tritiated estrogen in any of the tissues of the temporomandibular joint complex, including the articular surface of the condyle, articular disk, capsule, and muscles of mastication. However, estrogen receptors were identified in other tissues, including the pituitary. All tissues examined in the control animal were negative for estrogen receptors. It was concluded that there were no estrogen receptors in the temporomandibular joint complex of aged male baboons. As in previous studies, these findings provide additional evidence of a sexual dimorphism with respect to estrogen receptor distribution in the temporomandibular joint complex of the baboon. Furthermore, it is reasonable to speculate that estrogens may modulate a variety of metabolic functions in these tissues that could be important in the maintenance, repair, and/or pathogenesis of the temporomandibular joint.

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Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon

Abstract

Bibliographical note

ASJC Scopus subject areas

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