Shared heritability and functional enrichment across six solid cancers

Xia Jiang; Hilary K. Finucane; Fredrick R. Schumacher; Stephanie L. Schmit; Jonathan P. Tyrer; Younghun Han; Kyriaki Michailidou; Corina Lesseur; Karoline B. Kuchenbaecker; Joe Dennis; David V. Conti; Graham Casey; Mia M. Gaudet; Jeroen R. Huyghe; Demetrius Albanes; Melinda C. Aldrich; Angeline S. Andrew; Irene L. Andrulis; Hoda Anton-Culver; Antonis C. Antoniou; Natalia N. Antonenkova; Susanne M. Arnold; Kristan J. Aronson; Banu K. Arun; Elisa V. Bandera; Rosa B. Barkardottir; Daniel R. Barnes; Jyotsna Batra; Matthias W. Beckmann; Javier Benitez; Sara Benlloch; Andrew Berchuck; Sonja I. Berndt; Heike Bickeböller; Stephanie A. Bien; Carl Blomqvist; Stefania Boccia; Natalia V. Bogdanova; Stig E. Bojesen; Manjeet K. Bolla; Hiltrud Brauch; Hermann Brenner; James D. Brenton; Mark N. Brook; Joan Brunet; Hans Brunnström; Daniel D. Buchanan; Barbara Burwinkel; Ralf Butzow; Gabriella Cadoni; Trinidad Caldés; Maria A. Caligo; Ian Campbell; Peter T. Campbell; Géraldine Cancel-Tassin; Lisa Cannon-Albright; Daniele Campa; Neil Caporaso; André L. Carvalho; Andrew T. Chan; Jenny Chang-Claude; Stephen J. Chanock; Chu Chen; David C. Christiani; Kathleen B.M. Claes; Frank Claessens; Judith Clements; J. Margriet Collée; Marcia Cruz Correa; Fergus J. Couch; Angela Cox; Julie M. Cunningham; Cezary Cybulski; Kamila Czene; Mary B. Daly; Anna deFazio; Peter Devilee; Orland Diez; Manuela Gago-Dominguez; Jenny L. Donovan; Thilo Dörk; Eric J. Duell; Alison M. Dunning; Miriam Dwek; Diana M. Eccles; Christopher K. Edlund; Digna R.Velez Edwards; Carolina Ellberg; D. Gareth Evans; Peter A. Fasching; Robert L. Ferris; Triantafillos Liloglou; Jane C. Figueiredo; Olivia Fletcher; Renée T. Fortner; Florentia Fostira; Silvia Franceschi; Eitan Friedman; Steven J. Gallinger; Patricia A. Ganz; Judy Garber; José A. García-Sáenz; Simon A. Gayther; Graham G. Giles; Andrew K. Godwin; Mark S. Goldberg; David E. Goldgar; Ellen L. Goode; Marc T. Goodman; Gary Goodman; Kjell Grankvist; Mark H. Greene; Henrik Gronberg; Jacek Gronwald; Pascal Guénel; Niclas Håkansson; Per Hall; Ute Hamann; Freddie C. Hamdy; Robert J. Hamilton; Jochen Hampe; Aage Haugen; Florian Heitz; Rolando Herrero; Peter Hillemanns; Michael Hoffmeister; Estrid Høgdall; Yun Chul Hong; John L. Hopper; Richard Houlston; Peter J. Hulick; David J. Hunter; David G. Huntsman; Gregory Idos; Evgeny N. Imyanitov; Sue Ann Ingles; Claudine Isaacs; Anna Jakubowska; Paul James; Mark A. Jenkins; Mattias Johansson; Mikael Johansson; Esther M. John; Amit D. Joshi; Radka Kaneva; Beth Y. Karlan; Linda E. Kelemen; Tabea Kühl; Kay Tee Khaw; Elza Khusnutdinova; Adam S. Kibel; Lambertus A. Kiemeney; Jeri Kim; Susanne K. Kjaer; Julia A. Knight; Manolis Kogevinas; Zsofia Kote-Jarai; Stella Koutros; Vessela N. Kristensen; Jolanta Kupryjanczyk; Martin Lacko; Stephan Lam; Diether Lambrechts; Maria Teresa Landi; Philip Lazarus; Nhu D. Le; Eunjung Lee; Flavio Lejbkowicz; Heinz Josef Lenz; Goska Leslie; Davor Lessel; Jenny Lester; Douglas A. Levine; Li Li; Christopher I. Li; Annika Lindblom; Noralane M. Lindor; Geoffrey Liu; Fotios Loupakis; Jan Lubiński; Lovise Maehle; Christiane Maier; Arto Mannermaa; Loic Le Marchand; Sara Margolin; Taymaa May; Lesley McGuffog; Alfons Meindl; Pooja Middha; Austin Miller; Roger L. Milne; Robert J. MacInnis; Francesmary Modugno; Marco Montagna; Victor Moreno; Kirsten B. Moysich; Lorelei Mucci; Kenneth Muir; Anna Marie Mulligan; Katherine L. Nathanson; David E. Neal; Andrew R. Ness; Susan L. Neuhausen; Heli Nevanlinna; Polly A. Newcomb; Lisa F. Newcomb; Finn Cilius Nielsen; Liene Nikitina-Zake; Børge G. Nordestgaard; Robert L. Nussbaum; Kenneth Offit; Edith Olah; Ali Amin Al Olama; Olufunmilayo I. Olopade; Andrew F. Olshan; Håkan Olsson; Ana Osorio; Hardev Pandha; Jong Y. Park; Nora Pashayan; Michael T. Parsons; Tanja Pejovic; Kathryn L. Penney; Wilbert H.M. Peters; Catherine M. Phelan; Amanda I. Phipps; Dijana Plaseska-Karanfilska; Miranda Pring; Darya Prokofyeva; Paolo Radice; Kari Stefansson; Susan J. Ramus; Leon Raskin; Gad Rennert; Hedy S. Rennert; Elizabeth J. van Rensburg; Marjorie J. Riggan; Harvey A. Risch; Angela Risch; Monique J. Roobol; Barry S. Rosenstein; Mary Anne Rossing; Kim De Ruyck; Emmanouil Saloustros; Dale P. Sandler; Elinor J. Sawyer; Matthew B. Schabath; Johanna Schleutker; Marjanka K. Schmidt; V. Wendy Setiawan; Hongbing Shen; Erin M. Siegel; Weiva Sieh; Christian F. Singer; Martha L. Slattery; Karina Dalsgaard Sorensen; Melissa C. Southey; Amanda B. Spurdle; Janet L. Stanford; Victoria L. Stevens; Sebastian Stintzing; Jennifer Stone; Karin Sundfeldt; Rebecca Sutphen; Anthony J. Swerdlow; Eloiza H. Tajara; Catherine M. Tangen; Adonina Tardon; Jack A. Taylor; M. Dawn Teare; Manuel R. Teixeira; Mary Beth Terry; Kathryn L. Terry; Stephen N. Thibodeau; Mads Thomassen; Line Bjørge; Marc Tischkowitz; Amanda E. Toland; Diana Torres; Paul A. Townsend; Ruth C. Travis; Nadine Tung; Shelley S. Tworoger; Cornelia M. Ulrich; Nawaid Usmani; Celine M. Vachon; Els Van Nieuwenhuysen; Ana Vega; Miguel Elías Aguado-Barrera; Qin Wang; Penelope M. Webb; Clarice R. Weinberg; Stephanie Weinstein; Mark C. Weissler; Jeffrey N. Weitzel; Catharine M.L. West; Emily White; Alice S. Whittemore; H. Erich Wichmann; Fredrik Wiklund; Robert Winqvist; Alicja Wolk; Penella Woll; Michael Woods; Anna H. Wu; Xifeng Wu; Drakoulis Yannoukakos; Wei Zheng; Shanbeh Zienolddiny; Argyrios Ziogas; Kristin K. Zorn; Jacqueline M. Lane; Richa Saxena; Duncan Thomas; Rayjean J. Hung; Brenda Diergaarde; James McKay; Ulrike Peters; Li Hsu; Montserrat García-Closas; Rosalind A. Eeles; Georgia Chenevix-Trench; Paul J. Brennan; Christopher A. Haiman; Jacques Simard; Douglas F. Easton; Stephen B. Gruber; Paul D.P. Pharoah; Alkes L. Price; Bogdan Pasaniuc; Christopher I. Amos; Peter Kraft; Sara Lindström

doi:10.1038/s41467-018-08054-4

Shared heritability and functional enrichment across six solid cancers

Xia Jiang
, Hilary K. Finucane
, Fredrick R. Schumacher
, Stephanie L. Schmit
, Jonathan P. Tyrer
, Younghun Han
, Kyriaki Michailidou
, Corina Lesseur
, Karoline B. Kuchenbaecker
, Joe Dennis
, David V. Conti
, Graham Casey
, Mia M. Gaudet
, Jeroen R. Huyghe
, Demetrius Albanes
, Melinda C. Aldrich
, Angeline S. Andrew
, Irene L. Andrulis
, Hoda Anton-Culver
, Antonis C. Antoniou

Natalia N. Antonenkova, Susanne M. Arnold, Kristan J. Aronson, Banu K. Arun, Elisa V. Bandera, Rosa B. Barkardottir, Daniel R. Barnes, Jyotsna Batra, Matthias W. Beckmann, Javier Benitez, Sara Benlloch, Andrew Berchuck, Sonja I. Berndt, Heike Bickeböller, Stephanie A. Bien, Carl Blomqvist, Stefania Boccia, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Hiltrud Brauch, Hermann Brenner, James D. Brenton, Mark N. Brook, Joan Brunet, Hans Brunnström, Daniel D. Buchanan, Barbara Burwinkel, Ralf Butzow, Gabriella Cadoni, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Peter T. Campbell, Géraldine Cancel-Tassin, Lisa Cannon-Albright, Daniele Campa, Neil Caporaso, André L. Carvalho, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Chu Chen, David C. Christiani, Kathleen B.M. Claes, Frank Claessens, Judith Clements, J. Margriet Collée, Marcia Cruz Correa, Fergus J. Couch, Angela Cox, Julie M. Cunningham, Cezary Cybulski, Kamila Czene, Mary B. Daly, Anna deFazio, Peter Devilee, Orland Diez, Manuela Gago-Dominguez, Jenny L. Donovan, Thilo Dörk, Eric J. Duell, Alison M. Dunning, Miriam Dwek, Diana M. Eccles, Christopher K. Edlund, Digna R.Velez Edwards, Carolina Ellberg, D. Gareth Evans, Peter A. Fasching, Robert L. Ferris, Triantafillos Liloglou, Jane C. Figueiredo, Olivia Fletcher, Renée T. Fortner, Florentia Fostira, Silvia Franceschi, Eitan Friedman, Steven J. Gallinger, Patricia A. Ganz, Judy Garber, José A. García-Sáenz, Simon A. Gayther, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Ellen L. Goode, Marc T. Goodman, Gary Goodman, Kjell Grankvist, Mark H. Greene, Henrik Gronberg, Jacek Gronwald, Pascal Guénel, Niclas Håkansson, Per Hall, Ute Hamann, Freddie C. Hamdy, Robert J. Hamilton, Jochen Hampe, Aage Haugen, Florian Heitz, Rolando Herrero, Peter Hillemanns, Michael Hoffmeister, Estrid Høgdall, Yun Chul Hong, John L. Hopper, Richard Houlston, Peter J. Hulick, David J. Hunter, David G. Huntsman, Gregory Idos, Evgeny N. Imyanitov, Sue Ann Ingles, Claudine Isaacs, Anna Jakubowska, Paul James, Mark A. Jenkins, Mattias Johansson, Mikael Johansson, Esther M. John, Amit D. Joshi, Radka Kaneva, Beth Y. Karlan, Linda E. Kelemen, Tabea Kühl, Kay Tee Khaw, Elza Khusnutdinova, Adam S. Kibel, Lambertus A. Kiemeney, Jeri Kim, Susanne K. Kjaer, Julia A. Knight, Manolis Kogevinas, Zsofia Kote-Jarai, Stella Koutros, Vessela N. Kristensen, Jolanta Kupryjanczyk, Martin Lacko, Stephan Lam, Diether Lambrechts, Maria Teresa Landi, Philip Lazarus, Nhu D. Le, Eunjung Lee, Flavio Lejbkowicz, Heinz Josef Lenz, Goska Leslie, Davor Lessel, Jenny Lester, Douglas A. Levine, Li Li, Christopher I. Li, Annika Lindblom, Noralane M. Lindor, Geoffrey Liu, Fotios Loupakis, Jan Lubiński, Lovise Maehle, Christiane Maier, Arto Mannermaa, Loic Le Marchand, Sara Margolin, Taymaa May, Lesley McGuffog, Alfons Meindl, Pooja Middha, Austin Miller, Roger L. Milne, Robert J. MacInnis, Francesmary Modugno, Marco Montagna, Victor Moreno, Kirsten B. Moysich, Lorelei Mucci, Kenneth Muir, Anna Marie Mulligan, Katherine L. Nathanson, David E. Neal, Andrew R. Ness, Susan L. Neuhausen, Heli Nevanlinna, Polly A. Newcomb, Lisa F. Newcomb, Finn Cilius Nielsen, Liene Nikitina-Zake, Børge G. Nordestgaard, Robert L. Nussbaum, Kenneth Offit, Edith Olah, Ali Amin Al Olama, Olufunmilayo I. Olopade, Andrew F. Olshan, Håkan Olsson, Ana Osorio, Hardev Pandha, Jong Y. Park, Nora Pashayan, Michael T. Parsons, Tanja Pejovic, Kathryn L. Penney, Wilbert H.M. Peters, Catherine M. Phelan, Amanda I. Phipps, Dijana Plaseska-Karanfilska, Miranda Pring, Darya Prokofyeva, Paolo Radice, Kari Stefansson, Susan J. Ramus, Leon Raskin, Gad Rennert, Hedy S. Rennert, Elizabeth J. van Rensburg, Marjorie J. Riggan, Harvey A. Risch, Angela Risch, Monique J. Roobol, Barry S. Rosenstein, Mary Anne Rossing, Kim De Ruyck, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Matthew B. Schabath, Johanna Schleutker, Marjanka K. Schmidt, V. Wendy Setiawan, Hongbing Shen, Erin M. Siegel, Weiva Sieh, Christian F. Singer, Martha L. Slattery, Karina Dalsgaard Sorensen, Melissa C. Southey, Amanda B. Spurdle, Janet L. Stanford, Victoria L. Stevens, Sebastian Stintzing, Jennifer Stone, Karin Sundfeldt, Rebecca Sutphen, Anthony J. Swerdlow, Eloiza H. Tajara, Catherine M. Tangen, Adonina Tardon, Jack A. Taylor, M. Dawn Teare, Manuel R. Teixeira, Mary Beth Terry, Kathryn L. Terry, Stephen N. Thibodeau, Mads Thomassen, Line Bjørge, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Paul A. Townsend, Ruth C. Travis, Nadine Tung, Shelley S. Tworoger, Cornelia M. Ulrich, Nawaid Usmani, Celine M. Vachon, Els Van Nieuwenhuysen, Ana Vega, Miguel Elías Aguado-Barrera, Qin Wang, Penelope M. Webb, Clarice R. Weinberg, Stephanie Weinstein, Mark C. Weissler, Jeffrey N. Weitzel, Catharine M.L. West, Emily White, Alice S. Whittemore, H. Erich Wichmann, Fredrik Wiklund, Robert Winqvist, Alicja Wolk, Penella Woll, Michael Woods, Anna H. Wu, Xifeng Wu, Drakoulis Yannoukakos, Wei Zheng, Shanbeh Zienolddiny, Argyrios Ziogas, Kristin K. Zorn, Jacqueline M. Lane, Richa Saxena, Duncan Thomas, Rayjean J. Hung, Brenda Diergaarde, James McKay, Ulrike Peters, Li Hsu, Montserrat García-Closas, Rosalind A. Eeles, Georgia Chenevix-Trench, Paul J. Brennan, Christopher A. Haiman, Jacques Simard, Douglas F. Easton, Stephen B. Gruber, Paul D.P. Pharoah, Alkes L. Price, Bogdan Pasaniuc, Christopher I. Amos, Peter Kraft, Sara Lindström

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r_g = 0.57, p = 4.6 × 10⁻⁸), breast and ovarian cancer (r_g = 0.24, p = 7 × 10⁻⁵), breast and lung cancer (r_g = 0.18, p =1.5 × 10⁻⁶) and breast and colorectal cancer (r_g = 0.15, p = 1.1 × 10⁻⁴). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

Original language	English
Article number	431
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-08054-4
State	Published - Dec 1 2019

Bibliographical note

Publisher Copyright:
© 2019, The Author(s).

Funding

Funders	Funder number
European Commission
National Childhood Cancer Registry – National Cancer Institute	U01CA074783, U01CA098233, U24CA074794, R01CA060987, R01CA137178, U01CA098758, P30CA072720, U01CA206110, R01CA197350, R01CA128978, R35CA197449, U01CA188392, U01CA167462, R01CA176785, U01CA137088, R01CA076016, K07CA095666, R01CA142081, UM1CA176726, UM1CA167552, UM1CA167551, R01CA144034, ZIACP010145, R01CA063682, U01CA179715, U01CA058860, R01CA069664, K07CA080668, P30CA015704, U19CA203654, K07CA092044, U01CA074806, R01CA189184, K05CA154337, R03CA113148, R01CA054281, R01CA063678, U19CA148065, U01CA098216, P30CA051008, U19CA148107, R01CA042182, U01CA069417, P50CA125183, P50CA127003, R01CA144040, U01CA164973, R01CA083918, P30CA023108, R01CA116167, R01CA058598, R37CA070867, U01CA122839, U01CA074799, K07CA172294, P50CA119997, R01CA122443, R01CA106414, UM1CA186107, P50CA105009, R01CA090731, U10CA037429, R01CA074386, R01CA059045, R01CA112523, P50CA159981, R01CA189532, R01CA081488, P01CA017054, R01CA128931, R01CA148667, U01CA098710, P30CA014089, P01CA087969, P01CA196569, R01CA177150, UM1CA182876, U19CA148127, R01CA111703, UM1CA182883, R01CA089085, U54CA156733, R01CA097396, U01CA196386, P30CA016672, P30CA177558, K05CA175147, R01CA120120, U19CA148112, R01CA100374, UM1CA164920, R01CA192393, R01CA160669, P20CA090578, R01CA054419, UM1CA164917, P30CA008748, P30CA076292, R01CA077398, R01CA140286, P30CA047904, P30CA068485, R01CA201407, P50CA097190, P01CA055075, P50CA070907, R01CA092447, U01CA199277, U24CA074800, R01CA176568, P50CA058223, U01CA164930, R01CA151989, R01CA074850, U01CA181770, P30CA016056, R01CA092824, K22CA138563, P30CA015083, R01CA087538, P50CA136393, U01CA097735, R01CA064277, P50CA116201, R01CA080742, R01CA126841, R01CA063464, U19CA148537, R01CA149429, R01CA047147, R01CA067262, P01CA033619, R01CA047305, RC4CA153828, R01CA049449, R01CA048998, R01CA132839, K24CA169004, R01CA092039, UG1CA189974, R01CA076366, R03CA115195, R01CA095023, U01CA194393
NIH Office of the Director	S10OD020069
National Center for Advancing Translational Sciences (NCATS)	UL1TR000124, UL1TR000117, UL1TR000445
National Human Genome Research Institute	U01HG004798, U01HG004446, U01HG004438
Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse	R01DA017932, R01DA035825
National Institutes of Health/National Institute of Environmental Health Sciences	T32ES013678, ZIAES049033, ZIAES102245, P30ES010126, ZIAES044005
Wellcome Trust	076113
Seventh Framework Programme	669026, 223175, 294576, 232997
UK Medical Research Council, Engineering and Physical Sciences Research Council	G0401527, MR/N003284/1, MC_PC_14105
Horizon 2020 Framework Programme	633784, 634935
National Center for Research Resources	P20RR018787, S10RR025141
National Institute of General Medical Sciences DP2GM119177 Sophie Dumont National Institute of General Medical Sciences	P20GM103534
Australian National Health and Medical Research Council	251533, 504702, 310670, 1025142, 199600, 504715
National Institute of Mental Health, National Institutes of Health	R01MH107649
National Institute of Diabetes and Digestive and Kidney Diseases	P30DK058404, K01DK110267
Fogarty International Center Panama International Cooperative Biodiversity	D43TW009112
UK Industrial Decarbonization Research and Innovation Centre	MR/M012190/1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General
General Physics and Astronomy

Access to Document

10.1038/s41467-018-08054-4

Cite this

Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., Conti, D. V., Casey, G., Gaudet, M. M., Huyghe, J. R., Albanes, D., Aldrich, M. C., Andrew, A. S., Andrulis, I. L., Anton-Culver, H., ... Lindström, S. (2019). Shared heritability and functional enrichment across six solid cancers. Nature Communications, 10(1), Article 431. https://doi.org/10.1038/s41467-018-08054-4

@article{31d5b7d5d8c34ad48cbd969cdbd55c37,

title = "Shared heritability and functional enrichment across six solid cancers",

abstract = "Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 {\texttimes} 10−8), breast and ovarian cancer (rg = 0.24, p = 7 {\texttimes} 10−5), breast and lung cancer (rg = 0.18, p =1.5 {\texttimes} 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 {\texttimes} 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.",

author = "Xia Jiang and Finucane, \{Hilary K.\} and Schumacher, \{Fredrick R.\} and Schmit, \{Stephanie L.\} and Tyrer, \{Jonathan P.\} and Younghun Han and Kyriaki Michailidou and Corina Lesseur and Kuchenbaecker, \{Karoline B.\} and Joe Dennis and Conti, \{David V.\} and Graham Casey and Gaudet, \{Mia M.\} and Huyghe, \{Jeroen R.\} and Demetrius Albanes and Aldrich, \{Melinda C.\} and Andrew, \{Angeline S.\} and Andrulis, \{Irene L.\} and Hoda Anton-Culver and Antoniou, \{Antonis C.\} and Antonenkova, \{Natalia N.\} and Arnold, \{Susanne M.\} and Aronson, \{Kristan J.\} and Arun, \{Banu K.\} and Bandera, \{Elisa V.\} and Barkardottir, \{Rosa B.\} and Barnes, \{Daniel R.\} and Jyotsna Batra and Beckmann, \{Matthias W.\} and Javier Benitez and Sara Benlloch and Andrew Berchuck and Berndt, \{Sonja I.\} and Heike Bickeb{\"o}ller and Bien, \{Stephanie A.\} and Carl Blomqvist and Stefania Boccia and Bogdanova, \{Natalia V.\} and Bojesen, \{Stig E.\} and Bolla, \{Manjeet K.\} and Hiltrud Brauch and Hermann Brenner and Brenton, \{James D.\} and Brook, \{Mark N.\} and Joan Brunet and Hans Brunnstr{\"o}m and Buchanan, \{Daniel D.\} and Barbara Burwinkel and Ralf Butzow and Gabriella Cadoni and Trinidad Cald{\'e}s and Caligo, \{Maria A.\} and Ian Campbell and Campbell, \{Peter T.\} and G{\'e}raldine Cancel-Tassin and Lisa Cannon-Albright and Daniele Campa and Neil Caporaso and Carvalho, \{Andr{\'e} L.\} and Chan, \{Andrew T.\} and Jenny Chang-Claude and Chanock, \{Stephen J.\} and Chu Chen and Christiani, \{David C.\} and Claes, \{Kathleen B.M.\} and Frank Claessens and Judith Clements and Coll{\'e}e, \{J. Margriet\} and Correa, \{Marcia Cruz\} and Couch, \{Fergus J.\} and Angela Cox and Cunningham, \{Julie M.\} and Cezary Cybulski and Kamila Czene and Daly, \{Mary B.\} and Anna deFazio and Peter Devilee and Orland Diez and Manuela Gago-Dominguez and Donovan, \{Jenny L.\} and Thilo D{\"o}rk and Duell, \{Eric J.\} and Dunning, \{Alison M.\} and Miriam Dwek and Eccles, \{Diana M.\} and Edlund, \{Christopher K.\} and Edwards, \{Digna R.Velez\} and Carolina Ellberg and Evans, \{D. Gareth\} and Fasching, \{Peter A.\} and Ferris, \{Robert L.\} and Triantafillos Liloglou and Figueiredo, \{Jane C.\} and Olivia Fletcher and Fortner, \{Ren{\'e}e T.\} and Florentia Fostira and Silvia Franceschi and Eitan Friedman and Gallinger, \{Steven J.\} and Ganz, \{Patricia A.\} and Judy Garber and Garc{\'i}a-S{\'a}enz, \{Jos{\'e} A.\} and Gayther, \{Simon A.\} and Giles, \{Graham G.\} and Godwin, \{Andrew K.\} and Goldberg, \{Mark S.\} and Goldgar, \{David E.\} and Goode, \{Ellen L.\} and Goodman, \{Marc T.\} and Gary Goodman and Kjell Grankvist and Greene, \{Mark H.\} and Henrik Gronberg and Jacek Gronwald and Pascal Gu{\'e}nel and Niclas H{\aa}kansson and Per Hall and Ute Hamann and Hamdy, \{Freddie C.\} and Hamilton, \{Robert J.\} and Jochen Hampe and Aage Haugen and Florian Heitz and Rolando Herrero and Peter Hillemanns and Michael Hoffmeister and Estrid H{\o}gdall and Hong, \{Yun Chul\} and Hopper, \{John L.\} and Richard Houlston and Hulick, \{Peter J.\} and Hunter, \{David J.\} and Huntsman, \{David G.\} and Gregory Idos and Imyanitov, \{Evgeny N.\} and Ingles, \{Sue Ann\} and Claudine Isaacs and Anna Jakubowska and Paul James and Jenkins, \{Mark A.\} and Mattias Johansson and Mikael Johansson and John, \{Esther M.\} and Joshi, \{Amit D.\} and Radka Kaneva and Karlan, \{Beth Y.\} and Kelemen, \{Linda E.\} and Tabea K{\"u}hl and Khaw, \{Kay Tee\} and Elza Khusnutdinova and Kibel, \{Adam S.\} and Kiemeney, \{Lambertus A.\} and Jeri Kim and Kjaer, \{Susanne K.\} and Knight, \{Julia A.\} and Manolis Kogevinas and Zsofia Kote-Jarai and Stella Koutros and Kristensen, \{Vessela N.\} and Jolanta Kupryjanczyk and Martin Lacko and Stephan Lam and Diether Lambrechts and Landi, \{Maria Teresa\} and Philip Lazarus and Le, \{Nhu D.\} and Eunjung Lee and Flavio Lejbkowicz and Lenz, \{Heinz Josef\} and Goska Leslie and Davor Lessel and Jenny Lester and Levine, \{Douglas A.\} and Li Li and Li, \{Christopher I.\} and Annika Lindblom and Lindor, \{Noralane M.\} and Geoffrey Liu and Fotios Loupakis and Jan Lubi{\'n}ski and Lovise Maehle and Christiane Maier and Arto Mannermaa and Marchand, \{Loic Le\} and Sara Margolin and Taymaa May and Lesley McGuffog and Alfons Meindl and Pooja Middha and Austin Miller and Milne, \{Roger L.\} and MacInnis, \{Robert J.\} and Francesmary Modugno and Marco Montagna and Victor Moreno and Moysich, \{Kirsten B.\} and Lorelei Mucci and Kenneth Muir and Mulligan, \{Anna Marie\} and Nathanson, \{Katherine L.\} and Neal, \{David E.\} and Ness, \{Andrew R.\} and Neuhausen, \{Susan L.\} and Heli Nevanlinna and Newcomb, \{Polly A.\} and Newcomb, \{Lisa F.\} and Nielsen, \{Finn Cilius\} and Liene Nikitina-Zake and Nordestgaard, \{B{\o}rge G.\} and Nussbaum, \{Robert L.\} and Kenneth Offit and Edith Olah and Olama, \{Ali Amin Al\} and Olopade, \{Olufunmilayo I.\} and Olshan, \{Andrew F.\} and H{\aa}kan Olsson and Ana Osorio and Hardev Pandha and Park, \{Jong Y.\} and Nora Pashayan and Parsons, \{Michael T.\} and Tanja Pejovic and Penney, \{Kathryn L.\} and Peters, \{Wilbert H.M.\} and Phelan, \{Catherine M.\} and Phipps, \{Amanda I.\} and Dijana Plaseska-Karanfilska and Miranda Pring and Darya Prokofyeva and Paolo Radice and Kari Stefansson and Ramus, \{Susan J.\} and Leon Raskin and Gad Rennert and Rennert, \{Hedy S.\} and \{van Rensburg\}, \{Elizabeth J.\} and Riggan, \{Marjorie J.\} and Risch, \{Harvey A.\} and Angela Risch and Roobol, \{Monique J.\} and Rosenstein, \{Barry S.\} and Rossing, \{Mary Anne\} and \{De Ruyck\}, Kim and Emmanouil Saloustros and Sandler, \{Dale P.\} and Sawyer, \{Elinor J.\} and Schabath, \{Matthew B.\} and Johanna Schleutker and Schmidt, \{Marjanka K.\} and Setiawan, \{V. Wendy\} and Hongbing Shen and Siegel, \{Erin M.\} and Weiva Sieh and Singer, \{Christian F.\} and Slattery, \{Martha L.\} and Sorensen, \{Karina Dalsgaard\} and Southey, \{Melissa C.\} and Spurdle, \{Amanda B.\} and Stanford, \{Janet L.\} and Stevens, \{Victoria L.\} and Sebastian Stintzing and Jennifer Stone and Karin Sundfeldt and Rebecca Sutphen and Swerdlow, \{Anthony J.\} and Tajara, \{Eloiza H.\} and Tangen, \{Catherine M.\} and Adonina Tardon and Taylor, \{Jack A.\} and Teare, \{M. Dawn\} and Teixeira, \{Manuel R.\} and Terry, \{Mary Beth\} and Terry, \{Kathryn L.\} and Thibodeau, \{Stephen N.\} and Mads Thomassen and Line Bj{\o}rge and Marc Tischkowitz and Toland, \{Amanda E.\} and Diana Torres and Townsend, \{Paul A.\} and Travis, \{Ruth C.\} and Nadine Tung and Tworoger, \{Shelley S.\} and Ulrich, \{Cornelia M.\} and Nawaid Usmani and Vachon, \{Celine M.\} and \{Van Nieuwenhuysen\}, Els and Ana Vega and Aguado-Barrera, \{Miguel El{\'i}as\} and Qin Wang and Webb, \{Penelope M.\} and Weinberg, \{Clarice R.\} and Stephanie Weinstein and Weissler, \{Mark C.\} and Weitzel, \{Jeffrey N.\} and West, \{Catharine M.L.\} and Emily White and Whittemore, \{Alice S.\} and Wichmann, \{H. Erich\} and Fredrik Wiklund and Robert Winqvist and Alicja Wolk and Penella Woll and Michael Woods and Wu, \{Anna H.\} and Xifeng Wu and Drakoulis Yannoukakos and Wei Zheng and Shanbeh Zienolddiny and Argyrios Ziogas and Zorn, \{Kristin K.\} and Lane, \{Jacqueline M.\} and Richa Saxena and Duncan Thomas and Hung, \{Rayjean J.\} and Brenda Diergaarde and James McKay and Ulrike Peters and Li Hsu and Montserrat Garc{\'i}a-Closas and Eeles, \{Rosalind A.\} and Georgia Chenevix-Trench and Brennan, \{Paul J.\} and Haiman, \{Christopher A.\} and Jacques Simard and Easton, \{Douglas F.\} and Gruber, \{Stephen B.\} and Pharoah, \{Paul D.P.\} and Price, \{Alkes L.\} and Bogdan Pasaniuc and Amos, \{Christopher I.\} and Peter Kraft and Sara Lindstr{\"o}m",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

month = dec,

day = "1",

doi = "10.1038/s41467-018-08054-4",

language = "English",

volume = "10",

number = "1",

}

Jiang, X, Finucane, HK, Schumacher, FR, Schmit, SL, Tyrer, JP, Han, Y, Michailidou, K, Lesseur, C, Kuchenbaecker, KB, Dennis, J, Conti, DV, Casey, G, Gaudet, MM, Huyghe, JR, Albanes, D, Aldrich, MC, Andrew, AS, Andrulis, IL, Anton-Culver, H, Antoniou, AC, Antonenkova, NN, Arnold, SM, Aronson, KJ, Arun, BK, Bandera, EV, Barkardottir, RB, Barnes, DR, Batra, J, Beckmann, MW, Benitez, J, Benlloch, S, Berchuck, A, Berndt, SI, Bickeböller, H, Bien, SA, Blomqvist, C, Boccia, S, Bogdanova, NV, Bojesen, SE, Bolla, MK, Brauch, H, Brenner, H, Brenton, JD, Brook, MN, Brunet, J, Brunnström, H, Buchanan, DD, Burwinkel, B, Butzow, R, Cadoni, G, Caldés, T, Caligo, MA, Campbell, I, Campbell, PT, Cancel-Tassin, G, Cannon-Albright, L, Campa, D, Caporaso, N, Carvalho, AL, Chan, AT, Chang-Claude, J, Chanock, SJ, Chen, C, Christiani, DC, Claes, KBM, Claessens, F, Clements, J, Collée, JM, Correa, MC, Couch, FJ, Cox, A, Cunningham, JM, Cybulski, C, Czene, K, Daly, MB, deFazio, A, Devilee, P, Diez, O, Gago-Dominguez, M, Donovan, JL, Dörk, T, Duell, EJ, Dunning, AM, Dwek, M, Eccles, DM, Edlund, CK, Edwards, DRV, Ellberg, C, Evans, DG, Fasching, PA, Ferris, RL, Liloglou, T, Figueiredo, JC, Fletcher, O, Fortner, RT, Fostira, F, Franceschi, S, Friedman, E, Gallinger, SJ, Ganz, PA, Garber, J, García-Sáenz, JA, Gayther, SA, Giles, GG, Godwin, AK, Goldberg, MS, Goldgar, DE, Goode, EL, Goodman, MT, Goodman, G, Grankvist, K, Greene, MH, Gronberg, H, Gronwald, J, Guénel, P, Håkansson, N, Hall, P, Hamann, U, Hamdy, FC, Hamilton, RJ, Hampe, J, Haugen, A, Heitz, F, Herrero, R, Hillemanns, P, Hoffmeister, M, Høgdall, E, Hong, YC, Hopper, JL, Houlston, R, Hulick, PJ, Hunter, DJ, Huntsman, DG, Idos, G, Imyanitov, EN, Ingles, SA, Isaacs, C, Jakubowska, A, James, P, Jenkins, MA, Johansson, M, Johansson, M, John, EM, Joshi, AD, Kaneva, R, Karlan, BY, Kelemen, LE, Kühl, T, Khaw, KT, Khusnutdinova, E, Kibel, AS, Kiemeney, LA, Kim, J, Kjaer, SK, Knight, JA, Kogevinas, M, Kote-Jarai, Z, Koutros, S, Kristensen, VN, Kupryjanczyk, J, Lacko, M, Lam, S, Lambrechts, D, Landi, MT, Lazarus, P, Le, ND, Lee, E, Lejbkowicz, F, Lenz, HJ, Leslie, G, Lessel, D, Lester, J, Levine, DA, Li, L, Li, CI, Lindblom, A, Lindor, NM, Liu, G, Loupakis, F, Lubiński, J, Maehle, L, Maier, C, Mannermaa, A, Marchand, LL, Margolin, S, May, T, McGuffog, L, Meindl, A, Middha, P, Miller, A, Milne, RL, MacInnis, RJ, Modugno, F, Montagna, M, Moreno, V, Moysich, KB, Mucci, L, Muir, K, Mulligan, AM, Nathanson, KL, Neal, DE, Ness, AR, Neuhausen, SL, Nevanlinna, H, Newcomb, PA, Newcomb, LF, Nielsen, FC, Nikitina-Zake, L, Nordestgaard, BG, Nussbaum, RL, Offit, K, Olah, E, Olama, AAA, Olopade, OI, Olshan, AF, Olsson, H, Osorio, A, Pandha, H, Park, JY, Pashayan, N, Parsons, MT, Pejovic, T, Penney, KL, Peters, WHM, Phelan, CM, Phipps, AI, Plaseska-Karanfilska, D, Pring, M, Prokofyeva, D, Radice, P, Stefansson, K, Ramus, SJ, Raskin, L, Rennert, G, Rennert, HS, van Rensburg, EJ, Riggan, MJ, Risch, HA, Risch, A, Roobol, MJ, Rosenstein, BS, Rossing, MA, De Ruyck, K, Saloustros, E, Sandler, DP, Sawyer, EJ, Schabath, MB, Schleutker, J, Schmidt, MK, Setiawan, VW, Shen, H, Siegel, EM, Sieh, W, Singer, CF, Slattery, ML, Sorensen, KD, Southey, MC, Spurdle, AB, Stanford, JL, Stevens, VL, Stintzing, S, Stone, J, Sundfeldt, K, Sutphen, R, Swerdlow, AJ, Tajara, EH, Tangen, CM, Tardon, A, Taylor, JA, Teare, MD, Teixeira, MR, Terry, MB, Terry, KL, Thibodeau, SN, Thomassen, M, Bjørge, L, Tischkowitz, M, Toland, AE, Torres, D, Townsend, PA, Travis, RC, Tung, N, Tworoger, SS, Ulrich, CM, Usmani, N, Vachon, CM, Van Nieuwenhuysen, E, Vega, A, Aguado-Barrera, ME, Wang, Q, Webb, PM, Weinberg, CR, Weinstein, S, Weissler, MC, Weitzel, JN, West, CML, White, E, Whittemore, AS, Wichmann, HE, Wiklund, F, Winqvist, R, Wolk, A, Woll, P, Woods, M, Wu, AH, Wu, X, Yannoukakos, D, Zheng, W, Zienolddiny, S, Ziogas, A, Zorn, KK, Lane, JM, Saxena, R, Thomas, D, Hung, RJ, Diergaarde, B, McKay, J, Peters, U, Hsu, L, García-Closas, M, Eeles, RA, Chenevix-Trench, G, Brennan, PJ, Haiman, CA, Simard, J, Easton, DF, Gruber, SB, Pharoah, PDP, Price, AL, Pasaniuc, B, Amos, CI, Kraft, P & Lindström, S 2019, 'Shared heritability and functional enrichment across six solid cancers', Nature Communications, vol. 10, no. 1, 431. https://doi.org/10.1038/s41467-018-08054-4

TY - JOUR

T1 - Shared heritability and functional enrichment across six solid cancers

AU - Jiang, Xia

AU - Finucane, Hilary K.

AU - Schumacher, Fredrick R.

AU - Schmit, Stephanie L.

AU - Tyrer, Jonathan P.

AU - Han, Younghun

AU - Michailidou, Kyriaki

AU - Lesseur, Corina

AU - Kuchenbaecker, Karoline B.

AU - Dennis, Joe

AU - Conti, David V.

AU - Casey, Graham

AU - Gaudet, Mia M.

AU - Huyghe, Jeroen R.

AU - Albanes, Demetrius

AU - Aldrich, Melinda C.

AU - Andrew, Angeline S.

AU - Andrulis, Irene L.

AU - Anton-Culver, Hoda

AU - Antoniou, Antonis C.

AU - Antonenkova, Natalia N.

AU - Arnold, Susanne M.

AU - Aronson, Kristan J.

AU - Arun, Banu K.

AU - Bandera, Elisa V.

AU - Barkardottir, Rosa B.

AU - Barnes, Daniel R.

AU - Batra, Jyotsna

AU - Beckmann, Matthias W.

AU - Benitez, Javier

AU - Benlloch, Sara

AU - Berchuck, Andrew

AU - Berndt, Sonja I.

AU - Bickeböller, Heike

AU - Bien, Stephanie A.

AU - Blomqvist, Carl

AU - Boccia, Stefania

AU - Bogdanova, Natalia V.

AU - Bojesen, Stig E.

AU - Bolla, Manjeet K.

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Brenton, James D.

AU - Brook, Mark N.

AU - Brunet, Joan

AU - Brunnström, Hans

AU - Buchanan, Daniel D.

AU - Burwinkel, Barbara

AU - Butzow, Ralf

AU - Cadoni, Gabriella

AU - Caldés, Trinidad

AU - Caligo, Maria A.

AU - Campbell, Ian

AU - Campbell, Peter T.

AU - Cancel-Tassin, Géraldine

AU - Cannon-Albright, Lisa

AU - Campa, Daniele

AU - Caporaso, Neil

AU - Carvalho, André L.

AU - Chan, Andrew T.

AU - Chang-Claude, Jenny

AU - Chanock, Stephen J.

AU - Chen, Chu

AU - Christiani, David C.

AU - Claes, Kathleen B.M.

AU - Claessens, Frank

AU - Clements, Judith

AU - Collée, J. Margriet

AU - Correa, Marcia Cruz

AU - Couch, Fergus J.

AU - Cox, Angela

AU - Cunningham, Julie M.

AU - Cybulski, Cezary

AU - Czene, Kamila

AU - Daly, Mary B.

AU - deFazio, Anna

AU - Devilee, Peter

AU - Diez, Orland

AU - Gago-Dominguez, Manuela

AU - Donovan, Jenny L.

AU - Dörk, Thilo

AU - Duell, Eric J.

AU - Dunning, Alison M.

AU - Dwek, Miriam

AU - Eccles, Diana M.

AU - Edlund, Christopher K.

AU - Edwards, Digna R.Velez

AU - Ellberg, Carolina

AU - Evans, D. Gareth

AU - Fasching, Peter A.

AU - Ferris, Robert L.

AU - Liloglou, Triantafillos

AU - Figueiredo, Jane C.

AU - Fletcher, Olivia

AU - Fortner, Renée T.

AU - Fostira, Florentia

AU - Franceschi, Silvia

AU - Friedman, Eitan

AU - Gallinger, Steven J.

AU - Ganz, Patricia A.

AU - Garber, Judy

AU - García-Sáenz, José A.

AU - Gayther, Simon A.

AU - Giles, Graham G.

AU - Godwin, Andrew K.

AU - Goldberg, Mark S.

AU - Goldgar, David E.

AU - Goode, Ellen L.

AU - Goodman, Marc T.

AU - Goodman, Gary

AU - Grankvist, Kjell

AU - Greene, Mark H.

AU - Gronberg, Henrik

AU - Gronwald, Jacek

AU - Guénel, Pascal

AU - Håkansson, Niclas

AU - Hall, Per

AU - Hamann, Ute

AU - Hamdy, Freddie C.

AU - Hamilton, Robert J.

AU - Hampe, Jochen

AU - Haugen, Aage

AU - Heitz, Florian

AU - Herrero, Rolando

AU - Hillemanns, Peter

AU - Hoffmeister, Michael

AU - Høgdall, Estrid

AU - Hong, Yun Chul

AU - Hopper, John L.

AU - Houlston, Richard

AU - Hulick, Peter J.

AU - Hunter, David J.

AU - Huntsman, David G.

AU - Idos, Gregory

AU - Imyanitov, Evgeny N.

AU - Ingles, Sue Ann

AU - Isaacs, Claudine

AU - Jakubowska, Anna

AU - James, Paul

AU - Jenkins, Mark A.

AU - Johansson, Mattias

AU - Johansson, Mikael

AU - John, Esther M.

AU - Joshi, Amit D.

AU - Kaneva, Radka

AU - Karlan, Beth Y.

AU - Kelemen, Linda E.

AU - Kühl, Tabea

AU - Khaw, Kay Tee

AU - Khusnutdinova, Elza

AU - Kibel, Adam S.

AU - Kiemeney, Lambertus A.

AU - Kim, Jeri

AU - Kjaer, Susanne K.

AU - Knight, Julia A.

AU - Kogevinas, Manolis

AU - Kote-Jarai, Zsofia

AU - Koutros, Stella

AU - Kristensen, Vessela N.

AU - Kupryjanczyk, Jolanta

AU - Lacko, Martin

AU - Lam, Stephan

AU - Lambrechts, Diether

AU - Landi, Maria Teresa

AU - Lazarus, Philip

AU - Le, Nhu D.

AU - Lee, Eunjung

AU - Lejbkowicz, Flavio

AU - Lenz, Heinz Josef

AU - Leslie, Goska

AU - Lessel, Davor

AU - Lester, Jenny

AU - Levine, Douglas A.

AU - Li, Li

AU - Li, Christopher I.

AU - Lindblom, Annika

AU - Lindor, Noralane M.

AU - Liu, Geoffrey

AU - Loupakis, Fotios

AU - Lubiński, Jan

AU - Maehle, Lovise

AU - Maier, Christiane

AU - Mannermaa, Arto

AU - Marchand, Loic Le

AU - Margolin, Sara

AU - May, Taymaa

AU - McGuffog, Lesley

AU - Meindl, Alfons

AU - Middha, Pooja

AU - Miller, Austin

AU - Milne, Roger L.

AU - MacInnis, Robert J.

AU - Modugno, Francesmary

AU - Montagna, Marco

AU - Moreno, Victor

AU - Moysich, Kirsten B.

AU - Mucci, Lorelei

AU - Muir, Kenneth

AU - Mulligan, Anna Marie

AU - Nathanson, Katherine L.

AU - Neal, David E.

AU - Ness, Andrew R.

AU - Neuhausen, Susan L.

AU - Nevanlinna, Heli

AU - Newcomb, Polly A.

AU - Newcomb, Lisa F.

AU - Nielsen, Finn Cilius

AU - Nikitina-Zake, Liene

AU - Nordestgaard, Børge G.

AU - Nussbaum, Robert L.

AU - Offit, Kenneth

AU - Olah, Edith

AU - Olama, Ali Amin Al

AU - Olopade, Olufunmilayo I.

AU - Olshan, Andrew F.

AU - Olsson, Håkan

AU - Osorio, Ana

AU - Pandha, Hardev

AU - Park, Jong Y.

AU - Pashayan, Nora

AU - Parsons, Michael T.

AU - Pejovic, Tanja

AU - Penney, Kathryn L.

AU - Peters, Wilbert H.M.

AU - Phelan, Catherine M.

AU - Phipps, Amanda I.

AU - Plaseska-Karanfilska, Dijana

AU - Pring, Miranda

AU - Prokofyeva, Darya

AU - Radice, Paolo

AU - Stefansson, Kari

AU - Ramus, Susan J.

AU - Raskin, Leon

AU - Rennert, Gad

AU - Rennert, Hedy S.

AU - van Rensburg, Elizabeth J.

AU - Riggan, Marjorie J.

AU - Risch, Harvey A.

AU - Risch, Angela

AU - Roobol, Monique J.

AU - Rosenstein, Barry S.

AU - Rossing, Mary Anne

AU - De Ruyck, Kim

AU - Saloustros, Emmanouil

AU - Sandler, Dale P.

AU - Sawyer, Elinor J.

AU - Schabath, Matthew B.

AU - Schleutker, Johanna

AU - Schmidt, Marjanka K.

AU - Setiawan, V. Wendy

AU - Shen, Hongbing

AU - Siegel, Erin M.

AU - Sieh, Weiva

AU - Singer, Christian F.

AU - Slattery, Martha L.

AU - Sorensen, Karina Dalsgaard

AU - Southey, Melissa C.

AU - Spurdle, Amanda B.

AU - Stanford, Janet L.

AU - Stevens, Victoria L.

AU - Stintzing, Sebastian

AU - Stone, Jennifer

AU - Sundfeldt, Karin

AU - Sutphen, Rebecca

AU - Swerdlow, Anthony J.

AU - Tajara, Eloiza H.

AU - Tangen, Catherine M.

AU - Tardon, Adonina

AU - Taylor, Jack A.

AU - Teare, M. Dawn

AU - Teixeira, Manuel R.

AU - Terry, Mary Beth

AU - Terry, Kathryn L.

AU - Thibodeau, Stephen N.

AU - Thomassen, Mads

AU - Bjørge, Line

AU - Tischkowitz, Marc

AU - Toland, Amanda E.

AU - Torres, Diana

AU - Townsend, Paul A.

AU - Travis, Ruth C.

AU - Tung, Nadine

AU - Tworoger, Shelley S.

AU - Ulrich, Cornelia M.

AU - Usmani, Nawaid

AU - Vachon, Celine M.

AU - Van Nieuwenhuysen, Els

AU - Vega, Ana

AU - Aguado-Barrera, Miguel Elías

AU - Wang, Qin

AU - Webb, Penelope M.

AU - Weinberg, Clarice R.

AU - Weinstein, Stephanie

AU - Weissler, Mark C.

AU - Weitzel, Jeffrey N.

AU - West, Catharine M.L.

AU - White, Emily

AU - Whittemore, Alice S.

AU - Wichmann, H. Erich

AU - Wiklund, Fredrik

AU - Winqvist, Robert

AU - Wolk, Alicja

AU - Woll, Penella

AU - Woods, Michael

AU - Wu, Anna H.

AU - Wu, Xifeng

AU - Yannoukakos, Drakoulis

AU - Zheng, Wei

AU - Zienolddiny, Shanbeh

AU - Ziogas, Argyrios

AU - Zorn, Kristin K.

AU - Lane, Jacqueline M.

AU - Saxena, Richa

AU - Thomas, Duncan

AU - Hung, Rayjean J.

AU - Diergaarde, Brenda

AU - McKay, James

AU - Peters, Ulrike

AU - Hsu, Li

AU - García-Closas, Montserrat

AU - Eeles, Rosalind A.

AU - Chenevix-Trench, Georgia

AU - Brennan, Paul J.

AU - Haiman, Christopher A.

AU - Simard, Jacques

AU - Easton, Douglas F.

AU - Gruber, Stephen B.

AU - Pharoah, Paul D.P.

AU - Price, Alkes L.

AU - Pasaniuc, Bogdan

AU - Amos, Christopher I.

AU - Kraft, Peter

AU - Lindström, Sara

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

AB - Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

UR - https://www.scopus.com/pages/publications/85060528251

UR - https://www.scopus.com/pages/publications/85060528251#tab=citedBy

U2 - 10.1038/s41467-018-08054-4

DO - 10.1038/s41467-018-08054-4

M3 - Article

C2 - 30683880

AN - SCOPUS:85060528251

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 431

ER -

Shared heritability and functional enrichment across six solid cancers

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this